TBX5
TBX5，即胸腺素盒转录因子5，是一种转录因子，属于T-box家族成员之一。TBX5在心脏发育、肺部形成和一些肿瘤的发生中起着重要作用。其作用机制涉及到与DNA上的特定位点结合，调控下游基因的表达。TBX5通过影响多种信号通路，包括但不限于PI3K-AKT、Wnt/β-catenin等，调控细胞的增殖、分化和迁移。在生物学意义上，TBX5对心脏和肺部的正常发育至关重要，其表达异常与某些先天性心脏病和肺疾病相关。此外，TBX5在肺癌等多种肿瘤中的作用也受到关注，其可能通过影响细胞周期和转移相关基因的表达，促进肿瘤的发展和转移。
热销产品
Recombinant Human T-box transcription factor TBX5 (TBX5) (CSB-EP857866HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA995324(TBX5 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA995324(TBX5 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: CSB-PA995324(TBX5 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
TBX5 Antibodies
TBX5 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA023257GA01HU | TBX5 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA995324 | TBX5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA869654 | TBX5 Antibody | Human,Mouse,Rat | ELISA,IHC |
TBX5 Proteins
TBX5 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP857866HU CSB-BP857866HU CSB-MP857866HU CSB-EP857866HU-B |
Recombinant Human T-box transcription factor TBX5 (TBX5) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP857866HU | Recombinant Human T-box transcription factor TBX5 (TBX5) | E.coli |
