TM4SF1
TM4SF1（Transmembrane 4 L six family member 1）是Tetraspanin超家族中亚家族TM4SFs的一员，首次于1986年被鉴定。它具有Tetraspanin家族典型的四次跨膜结构，胞外含两个loop区EC1和EC2，其中EC2区可通过半胱氨酸残基与整合素α5β1结合，影响细胞的黏附和运动。C端胞质区包含PDZ结合域，可与Syntenin-1和Syntenin-2蛋白相互作用介导肿瘤细胞的增殖和转移。 TM4SF1在多种肿瘤细胞表面高表达，包括肺癌、乳腺癌、肝癌、结直肠癌及卵巢癌等，且能与脂质激酶、酪氨酸蛋白激酶等形成复合体，如可结合DDR1，激活PKC和JAK2-STAT3信号通路，促进细胞伪足延伸。初步的研究结果表明，TM4SF1作为具有酪氨酸蛋白激酶活性的单次跨膜受体1（DDR1）的辅助受体，调控下游的PKC/STAT3信号通路，从而影响乳腺癌向肺组织的转移。此外，TM4SF1也是具有新型内化途径的ADC靶点，这意味着它在抗体偶联药物（ADC）的设计和开发中可能具有潜在的应用价值。 于TM4SF1的药物研发处于初级阶段，尚未有成熟的药物应用于临床治疗。因此，对于TM4SF1的研究仍具有深远的意义和广阔的前景。
热销产品
● Recombinant Human Transmembrane 4 L6 family member 1(TM4SF1)-VLPs (Active)
验证数据
CSB-MP023615HU is detected by Mouse anti-6*His monoclonal antibody.The two bands respectively correspond to monomer, Homodimer.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TM4SF1 at 5μg/mL can bind Anti-TM4SF1 recombinant antibody(CSB-RA023615MA1HU)， the EC50 is 4.079-4.472 ng/mL.VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 95% as determined by SEC-HPLC.
● Recombinant Macaca fascicularis Transmembrane 4 L6 family member 1 (TM4SF1)-VLPs (Active)
验证数据
CSB-MP5031MOV is detected by Mouse anti-6*His monoclonal antibody.The two bands respectively correspond to monomer, Homodimer.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus TM4SF1 at 5μg/mL can bind Anti-TM4SF1 recombinant antibody(CSB-RA023615MA1HU)， the EC50 is 4.480-4.930 ng/mL.VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 95% as determined by SEC-HPLC
TM4SF1 Antibodies
TM4SF1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA009895 | TM4SF1 Antibody | Human,Mouse | IHC, ELISA |
| CSB-PA982780 | TM4SF1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA017058 | TM4SF1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA023615LA01HU | TM4SF1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA023615LD01HU | TM4SF1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA023615LC01HU | TM4SF1 Antibody, FITC conjugated | Human | |
| CSB-PA023615LB01HU | TM4SF1 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA023615MA1HU | TM4SF1 Recombinant Monoclonal Antibody | Human | ELISA, FC |
TM4SF1 Proteins
TM4SF1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023615HU CSB-EP023615HU CSB-BP023615HU CSB-EP023615HU-B |
Recombinant Human Transmembrane 4 L6 family member 1 (TM4SF1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF023615HU | Recombinant Human Transmembrane 4 L6 family member 1 (TM4SF1) | in vitro E.coli expression system |
| CSB-YP023615HU1 | Recombinant Human Transmembrane 4 L6 family member 1 (TM4SF1), partial | Yeast |
| CSB-MP023615HU | Recombinant Human Transmembrane 4 L6 family member 1(TM4SF1)-VLPs (Active) | Mammalian cell |
