UBE2E1

Ubiquitin-conjugating enzyme E2 E1 is a protein in humans that is encoded by UBE2E1 gene. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.