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bub3

Mitotic checkpoint protein BUB3is a protein in humans that is encoded by BUB3 gene. Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.

bub3 Antibodies

bub3 for Homo sapiens (Human)

bub3 Proteins

bub3 Proteins for Homo sapiens (Human)

bub3 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

bub3 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

bub3 Proteins for Bos taurus (Bovine)

bub3 Proteins for Dictyostelium discoideum (Slime mold)

bub3 Proteins for Pongo abelii (Sumatran orangutan)

bub3 Proteins for Mus musculus (Mouse)