fgfr2
FGFR2，即成纤维细胞生长因子受体2，别名FGFRβ、Bek、CFD1等。FGFR2是一种跨膜受体酪氨酸激酶，由人体细胞自身的基因编码，主要在胚胎发育、组织再生、细胞增殖和迁移等过程中发挥作用。FGFR2的作用机制涉及与多种成纤维细胞生长因子(FGF)配体结合，如FGF1、FGF2、FGF4、FGF5等，进而激活其内在的酪氨酸激酶活性，启动下游的信号传导途径，如RAS/RAF/MEK/ERK、PI3K/AKT等。FGFR2在生物学上的意义非常广泛，它参与调节多种细胞过程，包括细胞增殖、分化、迁移和存活。FGFR2的信号通路与组织发育、伤口愈合、肿瘤生长和血管生成等生理和病理过程密切相关。FGFR2的功能异常与多种疾病有关，尤其是与某些类型的癌症相关，如乳腺癌、胃癌、非小细胞肺癌等。在肿瘤中，FGFR2的突变或过表达可能导致细胞增殖失控和肿瘤血管生成，促进肿瘤的侵袭和转移。因此，FGFR2是肿瘤治疗中的一个潜在靶点，针对FGFR2的抑制剂正在被开发用于治疗相关癌症。
热销产品
FGFR2 Recombinant Monoclonal Antibody (CSB-RA154582A0HU)
验证数据
Western Blot
Positive WB detected in: Rat Brain whole cell lysate, Rat Lung whole cell lysate, Mouse Brain whole cell lysate
All lanes: FGFR2 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 93, 87, 93, 77, 92, 89, 86, 29, 80, 93, 97, 92, 41, 80, 80, 77, 80 kDa
Observed band size: 145 kDa
fgfr2 Antibodies
fgfr2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA008645GA01HU | FGFR2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA077444 | FGFR2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA000992 | FGFR2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA449267 | FGFR2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA151107 | FGFR2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA008645LA01HU | FGFR2 Antibody | Human | ELISA, IHC |
| CSB-PA008645LB01HU | FGFR2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008645LC01HU | FGFR2 Antibody, FITC conjugated | Human | |
| CSB-RA154582A0HU | FGFR2 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB |
fgfr2 Proteins
fgfr2 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008645CH1 CSB-EP008645CH1 CSB-BP008645CH1 CSB-MP008645CH1 CSB-EP008645CH1-B |
Recombinant Chicken Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008645CH | Recombinant Chicken Fibroblast growth factor receptor 2 (FGFR2) | in vitro E.coli expression system |
fgfr2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008645HU1 CSB-EP008645HU1 CSB-BP008645HU1 CSB-MP008645HU1 CSB-EP008645HU1-B |
Recombinant Human Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008645HU | Recombinant Human Fibroblast growth factor receptor 2 (FGFR2) | in vitro E.coli expression system |
fgfr2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008645MO1 CSB-EP008645MO1 CSB-BP008645MO1 CSB-MP008645MO1 CSB-EP008645MO1-B |
Recombinant Mouse Fibroblast growth factor receptor 2 (Fgfr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008645MO | Recombinant Mouse Fibroblast growth factor receptor 2 (Fgfr2) | in vitro E.coli expression system |
fgfr2 Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008645XBE1 CSB-EP008645XBE1 CSB-BP008645XBE1 CSB-MP008645XBE1 CSB-EP008645XBE1-B |
Recombinant Xenopus laevis Fibroblast growth factor receptor 2 (fgfr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008645XBE | Recombinant Xenopus laevis Fibroblast growth factor receptor 2 (fgfr2) | in vitro E.coli expression system |
fgfr2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008645DIL CSB-EP008645DIL CSB-BP008645DIL CSB-MP008645DIL CSB-EP008645DIL-B |
Recombinant Danio rerio Fibroblast growth factor receptor 2 (fgfr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
fgfr2 Proteins for Pleurodeles waltl (Iberian ribbed newt)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008645EWZ CSB-EP008645EWZ CSB-BP008645EWZ CSB-MP008645EWZ CSB-EP008645EWZ-B |
Recombinant Pleurodeles waltl Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
fgfr2 Proteins for Dugesia japonica (Planarian)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008645DMU CSB-EP008645DMU CSB-BP008645DMU CSB-MP008645DMU CSB-EP008645DMU-B |
Recombinant Dugesia japonica Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
fgfr2 Proteins for Notophthalmus viridescens (Eastern newt) (Triturus viridescens)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008645NEO CSB-EP008645NEO CSB-BP008645NEO CSB-MP008645NEO CSB-EP008645NEO-B |
Recombinant Notophthalmus viridescens Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
