myd88
MYD88，即髓样分化因子88。它是一种在造血干细胞和淋巴组织中表达的转录因子，广泛参与免疫信号的传递。MYD88的来源是人体自身的基因编码，它作为细胞内传递信号的关键衔接蛋白，主要介导多种Toll样受体（TLR）、白细胞介素1受体（IL-1R）及白细胞介素-18受体（IL-18R）的信号传递，在固有免疫中发挥显著作用。MYD88的作用机制涉及到它与各种受体的相互作用，通过其TIR结构域（Toll-白细胞介素1受体域）识别受体激活后的信号，进而招募并激活下游的信号分子，如IRAK（白细胞介素-1受体相关激酶）等。这导致核因子-κB（NF-κB）和MAPK（丝裂原活化蛋白激酶）等转录因子的激活，从而调节炎症因子的表达。MYD88的信号通路包括但不限于NF-κB通路、JAK-STAT3（酪氨酸激酶-信号转导子和转录激活子3）信号通路等，这些通路在细胞增殖、分化以及炎症反应中扮演关键角色。MYD88的生物学意义主要体现在其对固有免疫应答的调控上。它不仅参与病原体识别和炎症反应的启动，还与肿瘤、感染性疾病、自身免疫性疾病等的发病机制密切相关。MYD88依赖的信号通路被认为是这些疾病治疗的潜在靶点。特别是，MYD88基因的某些突变，如L265P，可以导致炎症因子产生增加，这在淋巴浆细胞淋巴瘤等疾病中尤为重要。因此，对MYD88的研究不仅有助于我们理解免疫应答的复杂性，也为开发新的治疗策略提供了可能。
热销产品
Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88) (CSB-EP859945HU)
验证数据
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP859945HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MYD88.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP859945HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MYD88.
MYD88 Antibody (CSB-PA859945LA01HU)
验证数据
Immunofluorescent analysis of HepG2 cells using CSB-PA859945LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human myeloid differentiation factor 88, MyD88 ELISA Kit (CSB-E11747h)
验证数据
货号：CSB-E11747h
规格：96T/48T
灵敏度：0.078 ng/mL
检测范围：0.312ng/mL-20ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
myd88 Antibodies
myd88 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA003338 | MYD88 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA995911 | MYD88 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA859945LA01HU | MYD88 Antibody | Human | ELISA, IF |
| CSB-PA859945LB01HU | MYD88 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA859945LC01HU | MYD88 Antibody, FITC conjugated | Human | |
| CSB-PA859945LD01HU | MYD88 Antibody, Biotin conjugated | Human | ELISA |
myd88 Proteins
myd88 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282MO CSB-EP015282MO CSB-BP015282MO CSB-MP015282MO CSB-EP015282MO-B |
Recombinant Mouse Myeloid differentiation primary response protein MyD88 (Myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282PI CSB-EP015282PI CSB-BP015282PI CSB-MP015282PI CSB-EP015282PI-B |
Recombinant Pig Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282CH CSB-EP015282CH CSB-BP015282CH CSB-MP015282CH CSB-EP015282CH-B |
Recombinant Chicken Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Macaca mulatta (Rhesus macaque)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282MOW CSB-EP015282MOW CSB-BP015282MOW CSB-MP015282MOW CSB-EP015282MOW-B |
Recombinant Macaca mulatta (Rhesus macaque) Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Ovis aries (Sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282SH CSB-EP015282SH CSB-BP015282SH CSB-MP015282SH CSB-EP015282SH-B |
Recombinant Sheep Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282TKY CSB-EP015282TKY CSB-BP015282TKY CSB-MP015282TKY CSB-EP015282TKY-B |
Recombinant Takifugu rubripes Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Salmo salar (Atlantic salmon)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282SWI CSB-EP015282SWI CSB-BP015282SWI CSB-MP015282SWI CSB-EP015282SWI-B |
Recombinant Salmo salar Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282MOV CSB-EP015282MOV CSB-BP015282MOV CSB-MP015282MOV CSB-EP015282MOV-B |
Recombinant Macaca fascicularis Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282GGZ CSB-EP015282GGZ CSB-BP015282GGZ CSB-MP015282GGZ CSB-EP015282GGZ-B |
Recombinant Gorilla gorilla gorilla Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Pan troglodytes (Chimpanzee)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282EQV CSB-EP015282EQV CSB-BP015282EQV CSB-MP015282EQV CSB-EP015282EQV-B |
Recombinant Pan troglodytes Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282EQU CSB-EP015282EQU CSB-BP015282EQU CSB-MP015282EQU CSB-EP015282EQU-B |
Recombinant Pan paniscus Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Pongo pygmaeus (Bornean orangutan)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282EXP CSB-EP015282EXP CSB-BP015282EXP CSB-MP015282EXP CSB-EP015282EXP-B |
Recombinant Pongo pygmaeus Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015282DRI CSB-EP015282DRI CSB-BP015282DRI CSB-MP015282DRI CSB-EP015282DRI-B |
Recombinant Cercocebus atys Myeloid differentiation primary response protein MyD88 (Myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP635725XBF CSB-EP635725XBF CSB-BP635725XBF CSB-MP635725XBF CSB-EP635725XBF-B |
Recombinant Xenopus tropicalis Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP685436BO CSB-EP685436BO CSB-BP685436BO CSB-MP685436BO CSB-EP685436BO-B |
Recombinant Bovine Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP708955OEI CSB-EP708955OEI CSB-BP708955OEI CSB-MP708955OEI CSB-EP708955OEI-B |
Recombinant Oncorhynchus mykiss Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP730396DIL CSB-EP730396DIL CSB-BP730396DIL CSB-MP730396DIL CSB-EP730396DIL-B |
Recombinant Danio rerio Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP744333RA CSB-EP744333RA CSB-BP744333RA CSB-MP744333RA CSB-EP744333RA-B |
Recombinant Rat Myeloid differentiation primary response protein MyD88 (Myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP859945HU CSB-BP859945HU CSB-MP859945HU CSB-EP859945HU-B |
Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
myd88 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-EP859945HU | Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88) | E.coli |
myd88 ELISA Kit
myd88 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E11747h | Human myeloid differentiation factor 88, MyD88 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
myd88 ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E12109m | Mouse myeloid differentiation factor 88, MyD88 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 11.7 pg/mL |
