ppara
PPARA，即过氧化物酶体增殖物激活受体α，别名包括PPARα、NR1C1。PPARA是一种核受体，属于PPAR家族成员之一，由人体细胞自身的基因编码。PPARA在肝脏、心脏、骨骼肌、肾脏和棕色脂肪组织等多种组织中表达。其作用机制主要是通过与特定的配体结合，如脂肪酸和其衍生物，激活受体，形成异源二聚体与DNA上的PPAR响应元件（PPREs）结合，调控下游基因的表达，从而参与脂质代谢、能量平衡和细胞增殖等过程。PPARA在生物学上的意义非常广泛，它在调节脂肪酸氧化、胆固醇代谢、炎症反应、细胞分化和肿瘤发生等方面发挥关键作用。PPARA的激活可以促进线粒体脂肪酸氧化，提高能量代谢效率，降低血浆中的胆固醇和甘油三酯水平，对抗动脉粥样硬化。此外，PPARA还参与调节肝脏的解毒功能，影响药物和毒物的代谢。PPARA的激动剂，如纤维酸类药物，被广泛用于治疗高脂血症和相关心血管疾病。因此，PPARA是代谢性疾病和心血管疾病研究和治疗中的一个重要靶点。
热销产品
Recombinant Human Peroxisome proliferator-activated receptor alpha (PPARA) (CSB-BP018421HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of Baculovirus host and target protein, the LC-MS/MS Analysis result of CSB-BP018421HU could indicate that this peptide derived from Baculovirus-expressed Homo sapiens (Human) PPARA.
Based on the SEQUEST from database of Baculovirus host and target protein, the LC-MS/MS Analysis result of CSB-BP018421HU could indicate that this peptide derived from Baculovirus-expressed Homo sapiens (Human) PPARA.
验证数据
Western Blot analysis of 3T3 cells using PPAR-α Polyclonal Antibody
Human peroxisome proliferators activator receptors alpha,PPAR-α ELISA Kit (CSB-E09754h)
验证数据
货号：CSB-E09754h
规格：96T/48T
灵敏度：19.5 pg/mL
检测范围：78 pg/mL-5000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ppara Antibodies
ppara for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA018421GA01HU | PPARA Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA030137 | PPARA Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA945095 | PPARA Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA112569 | PPARA Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA018421LA01HU | PPARA Antibody | Human | ELISA, WB |
| CSB-PA018421LB01HU | PPARA Antibody,HRP conjugated | Human | ELISA |
| CSB-PA018421LC01HU | PPARA Antibody，FITC conjugated | Human | |
| CSB-PA018421LD01HU | PPARA Antibody，Biotin conjugated | Human | ELISA |
ppara Proteins
ppara Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018421MO CSB-EP018421MO CSB-BP018421MO CSB-MP018421MO CSB-EP018421MO-B |
Recombinant Mouse Peroxisome proliferator-activated receptor alpha (Ppara) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ppara Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018421RA CSB-EP018421RA CSB-BP018421RA CSB-MP018421RA CSB-EP018421RA-B |
Recombinant Rat Peroxisome proliferator-activated receptor alpha (Ppara) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ppara Proteins for Cavia porcellus (Guinea pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018421GU CSB-EP018421GU CSB-BP018421GU CSB-MP018421GU CSB-EP018421GU-B |
Recombinant Guinea pig Peroxisome proliferator-activated receptor alpha (PPARA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ppara Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018421XBE CSB-EP018421XBE CSB-BP018421XBE CSB-MP018421XBE CSB-EP018421XBE-B |
Recombinant Xenopus laevis Peroxisome proliferator-activated receptor alpha (ppara) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ppara Proteins for Phascolarctos cinereus (Koala)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018421EUM CSB-EP018421EUM CSB-BP018421EUM CSB-MP018421EUM CSB-EP018421EUM-B |
Recombinant Phascolarctos cinereus Peroxisome proliferator-activated receptor alpha (PPARA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ppara Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018421DO CSB-EP018421DO CSB-BP018421DO CSB-MP018421DO CSB-EP018421DO-B |
Recombinant Dog Peroxisome proliferator-activated receptor alpha (PPARA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ppara Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-BP018421HU | Recombinant Human Peroxisome proliferator-activated receptor alpha (PPARA) | Baculovirus |
ppara ELISA Kit
ppara ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E09754h | Human peroxisome proliferators activator receptors alpha,PPAR-α ELISA Kit | serum, plasma, tissue homogenates | 19.5 pg/mL |
ppara ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E09755r | Rat peroxisome proliferators activator receptors alpha,PPAR-α ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
