tigar
TIGAR,即TP53诱导的糖酵解和凋亡调节剂,别名FR2BP、C12orf5。它是一种在细胞对p53相关应激反应中起重要作用的蛋白,由人体细胞自身的基因编码。TIGAR的作用机制主要是通过抑制糖酵解途径,增加磷酸戊糖途径的流量,从而产生更多的NADPH,以促进DNA修复和减少细胞内活性氧(ROS)的产生,保护细胞免受氧化应激引起的损伤。TIGAR在生物学上的意义非常广泛,它参与调节细胞的代谢、氧化还原平衡、细胞周期、细胞凋亡以及自噬等过程。TIGAR的表达与多种疾病的发生发展密切相关,尤其是在肿瘤发展中,TIGAR通过抗氧化作用和调节自噬,有助于肿瘤细胞逃避免疫监视和增强肿瘤细胞的侵袭能力。此外,TIGAR的功能异常还与某些心血管疾病和神经退行性疾病相关。因此,TIGAR是药物开发和疾病治疗中的一个潜在靶点。
热销产品
TIGAR Antibody (CSB-PA889078LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA889078LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA889078LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA889078LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
tigar Antibodies
tigar for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA202764 | TIGAR Antibody | Human | ELISA,IHC |
CSB-PA162542 | TIGAR Antibody | Human | ELISA,WB,IHC |
CSB-PA889078LA01HU | TIGAR Antibody | Human | ELISA, IHC, IF |
CSB-PA889078LC01HU | TIGAR Antibody, FITC conjugated | Human | |
CSB-PA889078LD01HU | TIGAR Antibody, Biotin conjugated | Human | ELISA |
tigar Proteins
tigar Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP889078HU CSB-EP889078HU CSB-BP889078HU CSB-MP889078HU CSB-EP889078HU-B |
Recombinant Human Probable fructose-2,6-bisphosphatase TIGAR (TIGAR) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP000111HU | Recombinant Human Fructose-2,6-bisphosphatase TIGAR protein (TIGAR) | E.Coli |