Your Good Partner in Biology Research

  1. 首页
  2. 试剂盒
  3. 酶联免疫试剂盒
  4. Human Matrix metalloproteinase-21(MMP21) ELISA kit

Human Matrix metalloproteinase-21(MMP21) ELISA kit

  • 中文名称：
    人基质金属蛋白酶-21(MMP21)酶联免疫试剂盒
  • 货号：
    CSB-EL014668HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human MMP21 ELISA Kit was designed for the quantitative measurement of Human MMP21 protein in serum, plasma,tissue homogenates. It is a Sandwich ELISA kit, its detection range is 1.56 ng/mL-100 ng/mL and the sensitivity is 0.39 ng/mL.

  • 别名：
    MMP21Matrix metalloproteinase-21 ELISA Kit; MMP-21 ELISA Kit; EC 3.4.24.- ELISA Kit
  • 缩写：
    MMP21
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma,tissue homogenates
  • 检测范围：
    1.56 ng/mL-100 ng/mL
  • 灵敏度：
    0.39 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cancer
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

引用文献

产品评价

靶点详情

  • 功能：
    Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin.
  • 基因功能参考文献：
    1. MMP-21 572TT genotype increased the risk for the HIV-associated neurocognitive disorder. PMID: 29575199
    2. loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling. PMID: 26429889
    3. Data show that MMP21 (encoding matrix metallopeptidase 21) point mutations were verified by Sanger sequencing, and segregation analysis indicated recessive inheritance. PMID: 26437028
    4. Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and lymph node metastasis. PMID: 25015395
    5. These results suggest that high MMP-21 expression in lymph node metastatic foci can be used to predict survival in OSCC patients with LNM PMID: 24700287
    6. analysis proved MMP-21 to be an independent prognostic factor for overall survival of gastric cancer patients PMID: 23275114
    7. MMP-21 expression is elevated in primary CRC and related to tumor invasion and metastasis. MMP-21 was also proved to be an independent prognostic factor for patients with stage II and stage III colorectal cancer. PMID: 21656525
    8. MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation. PMID: 19601983
    9. MMP-21 was expressed by Merkel cell carcinoma cells in 13/43 cases and in eight samples by stromal neutrophils. None of the samples with MMP-21-expressing neutrophils had metastasized to the lymph nodes PMID: 19921252
    10. The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer. PMID: 15015597
    11. MMP-21 is not a marker of invasiveness, but rather of differentiation, in pancreatic cancer PMID: 17873896
    12. MMP-21 may be an important protease in the terminal differentiation of keratinocytes PMID: 18633436
    13. A nonsynchronous polymorphism in the MMP-21 promoter does not significantly confer susceptibility to hepatocellular carcinoma in a southern Chinese population. PMID: 18768525

    显示更多

    收起更多

  • 相关疾病：
    Heterotaxy, visceral, 7, autosomal (HTX7)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
  • 数据库链接：

    HGNC: 14357

    OMIM: 608416

    KEGG: hsa:118856

    STRING: 9606.ENSP00000357798

    UniGene: Hs.314141