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  4. MMP21 Antibody

MMP21 Antibody

  • 货号：
    CSB-PA729577
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA729577(MMP21 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA729577(MMP21 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8N119
  • 基因名：
    MMP21
  • 别名：
    MMP21Matrix metalloproteinase-21 antibody; MMP-21 antibody; EC 3.4.24.- antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human MMP21
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin.
  • 基因功能参考文献：
    1. MMP-21 572TT genotype increased the risk for the HIV-associated neurocognitive disorder. PMID: 29575199
    2. loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling. PMID: 26429889
    3. Data show that MMP21 (encoding matrix metallopeptidase 21) point mutations were verified by Sanger sequencing, and segregation analysis indicated recessive inheritance. PMID: 26437028
    4. Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and lymph node metastasis. PMID: 25015395
    5. These results suggest that high MMP-21 expression in lymph node metastatic foci can be used to predict survival in OSCC patients with LNM PMID: 24700287
    6. analysis proved MMP-21 to be an independent prognostic factor for overall survival of gastric cancer patients PMID: 23275114
    7. MMP-21 expression is elevated in primary CRC and related to tumor invasion and metastasis. MMP-21 was also proved to be an independent prognostic factor for patients with stage II and stage III colorectal cancer. PMID: 21656525
    8. MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation. PMID: 19601983
    9. MMP-21 was expressed by Merkel cell carcinoma cells in 13/43 cases and in eight samples by stromal neutrophils. None of the samples with MMP-21-expressing neutrophils had metastasized to the lymph nodes PMID: 19921252
    10. The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer. PMID: 15015597
    11. MMP-21 is not a marker of invasiveness, but rather of differentiation, in pancreatic cancer PMID: 17873896
    12. MMP-21 may be an important protease in the terminal differentiation of keratinocytes PMID: 18633436
    13. A nonsynchronous polymorphism in the MMP-21 promoter does not significantly confer susceptibility to hepatocellular carcinoma in a southern Chinese population. PMID: 18768525

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  • 相关疾病：
    Heterotaxy, visceral, 7, autosomal (HTX7)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
  • 数据库链接：

    HGNC: 14357

    OMIM: 608416

    KEGG: hsa:118856

    STRING: 9606.ENSP00000357798

    UniGene: Hs.314141