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  4. Human Protein FAM3C(FAM3C) ELISA kit

Human Protein FAM3C(FAM3C) ELISA kit

  • 中文名称：
    人FAM3C蛋白(FAM3C)酶联免疫试剂盒
  • 货号：
    CSB-EL008228HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 别名：
    Fam3c ELISA Kit; FAM3C_HUMAN ELISA Kit; Family with sequence similarity 3 member C ELISA Kit; GS3786 ELISA Kit; ILEI ELISA Kit; Interleukin-like EMT inducer ELISA Kit; Predicted osteoblast protein ELISA Kit; Protein FAM3C ELISA Kit
  • 缩写：
    FAM3C
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    1.56 ng/ml - 100 ng/ml
  • 灵敏度：
    0.39 ng/ml
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 线性度：
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
  • 基因功能参考文献：
    1. The ILEI appears to play a crucial role in mediating TGF-beta1-induced EMT through the Akt and ERK pathways, which may provide a therapeutic target for the treatment of fibrotic kidney diseases. PMID: 29336056
    2. Covalent dimerization of ILEI is associated with breast cancer metastasis. PMID: 28837266
    3. Data suggest that ILEI does not form interleukin-like four helix-bundle structures; ILEI exists as monomers and as covalent dimers; ILEI dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric ILEI appears to be involved in neoplastic invasiveness. PMID: 28751379
    4. Results demonstrate that phenotype switching regulates ILEI expression, and that ILEI regulates partial phenotype switching in MITF-low melanoma cell lines. PMID: 28545079
    5. Ectopic overexpression of UBE4A, but not UBE3C, in cells was downregulated in vitro migration and invasion in these cells. Cumulatively, our data reveals a novel post-translational regulatory mechanism of regulating ILEI1 expression, a protein required for metastatic progression in prostate cancer cells PMID: 27862841
    6. Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta in the brain and the eventual development of Alzheimer's disease. PMID: 27256505
    7. FAM3C expression was dramatically increased in esophageal squamous cell carcinoma and might serve as a valuable prognostic indicator for esophageal squamous cell carcinoma patients after surgery PMID: 26498278
    8. Altered subcellular ILEI localization strongly correlates with high tumor cell-associated uPAR protein expression. PMID: 25212966
    9. Our findings indicate that cytoplasmic ILEI expression is a potential marker of EMT and tumour progression in colorectal cancer. ILEI is an independent predictive factor associated with poor prognosis in colorectal cancer. PMID: 24738665
    10. ILEI could induce, as well as maintain, CD24(low)CD44(high) subpopulation in A549 cells treated with TGF-beta, which might explain its capability to induce metastatic progression. PMID: 24072492
    11. At the FAM3C gene locus where rs7776725 was located, we identified several other SNPs (rs4727922, rs1803389, rs718766 and rs7793554) that were also associated with BMD. PMID: 22159821
    12. A cytokine-like protein found in almost all tissues. PMID: 12160727
    13. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors. PMID: 16959614
    14. Data show that FAM3C is decreased in the CSF of temporal lobe epilepsy patients. PMID: 19109932

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  • 亚细胞定位：
    Secreted. Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells.
  • 蛋白家族：
    FAM3 family
  • 组织特异性：
    Present in most secretory epithelia (at protein level).
  • 数据库链接：

    HGNC: 18664

    OMIM: 608618

    KEGG: hsa:10447

    STRING: 9606.ENSP00000353025

    UniGene: Hs.272375