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  4. Recombinant Human Protein FAM3C (FAM3C)

Recombinant Human Protein FAM3C (FAM3C)

  • 中文名称：
    人FAM3C重组蛋白
  • 货号：
    CSB-YP856401HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FAM3C重组蛋白
  • 货号：
    CSB-EP856401HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FAM3C重组蛋白
  • 货号：
    CSB-EP856401HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FAM3C重组蛋白
  • 货号：
    CSB-BP856401HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FAM3C重组蛋白
  • 货号：
    CSB-MP856401HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FAM3C
  • Uniprot No.：
  • 别名：
    Fam3c; FAM3C_HUMAN; Family with sequence similarity 3 member C; GS3786; ILEI; Interleukin-like EMT inducer; Predicted osteoblast protein; Protein FAM3C
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-227
  • 氨基酸序列
    QVFEIK MDASLGNLFA RSALDTAARS TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV GRGINVALAN GKTGEVLDTK YFDMWGGDVA PFIEFLKAIQ DGTIVLMGTY DDGATKLNDE ARRLIADLGS TSITNLGFRD NWVFCGGKGI KTKSPFEQHI KNNKDTNKYE GWPEVVEMEG CIPQKQD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
  • 基因功能参考文献：
    1. The ILEI appears to play a crucial role in mediating TGF-beta1-induced EMT through the Akt and ERK pathways, which may provide a therapeutic target for the treatment of fibrotic kidney diseases. PMID: 29336056
    2. Covalent dimerization of ILEI is associated with breast cancer metastasis. PMID: 28837266
    3. Data suggest that ILEI does not form interleukin-like four helix-bundle structures; ILEI exists as monomers and as covalent dimers; ILEI dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric ILEI appears to be involved in neoplastic invasiveness. PMID: 28751379
    4. Results demonstrate that phenotype switching regulates ILEI expression, and that ILEI regulates partial phenotype switching in MITF-low melanoma cell lines. PMID: 28545079
    5. Ectopic overexpression of UBE4A, but not UBE3C, in cells was downregulated in vitro migration and invasion in these cells. Cumulatively, our data reveals a novel post-translational regulatory mechanism of regulating ILEI1 expression, a protein required for metastatic progression in prostate cancer cells PMID: 27862841
    6. Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta in the brain and the eventual development of Alzheimer's disease. PMID: 27256505
    7. FAM3C expression was dramatically increased in esophageal squamous cell carcinoma and might serve as a valuable prognostic indicator for esophageal squamous cell carcinoma patients after surgery PMID: 26498278
    8. Altered subcellular ILEI localization strongly correlates with high tumor cell-associated uPAR protein expression. PMID: 25212966
    9. Our findings indicate that cytoplasmic ILEI expression is a potential marker of EMT and tumour progression in colorectal cancer. ILEI is an independent predictive factor associated with poor prognosis in colorectal cancer. PMID: 24738665
    10. ILEI could induce, as well as maintain, CD24(low)CD44(high) subpopulation in A549 cells treated with TGF-beta, which might explain its capability to induce metastatic progression. PMID: 24072492
    11. At the FAM3C gene locus where rs7776725 was located, we identified several other SNPs (rs4727922, rs1803389, rs718766 and rs7793554) that were also associated with BMD. PMID: 22159821
    12. A cytokine-like protein found in almost all tissues. PMID: 12160727
    13. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors. PMID: 16959614
    14. Data show that FAM3C is decreased in the CSF of temporal lobe epilepsy patients. PMID: 19109932

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  • 亚细胞定位：
    Secreted. Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells.
  • 蛋白家族：
    FAM3 family
  • 组织特异性：
    Present in most secretory epithelia (at protein level).
  • 数据库链接：

    HGNC: 18664

    OMIM: 608618

    KEGG: hsa:10447

    STRING: 9606.ENSP00000353025

    UniGene: Hs.272375