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  4. Mouse Apolipoprotein A-II(APOA2) ELISA kit

Mouse Apolipoprotein A-II(APOA2) ELISA kit

  • 中文名称：
    小鼠载脂蛋白A-II(APOA2)酶联免疫试剂盒
  • 货号：
    CSB-EL001915MO
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Mouse APOA2 ELISA Kit was designed for the quantitative measurement of Mouse APOA2 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 3.9 ng/mL-250 ng/mL and the sensitivity is 0.98 ng/mL.

  • 别名：
    Apoa2Apolipoprotein A-II ELISA kit; Apo-AII ELISA kit; ApoA-II ELISA kit; Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II ELISA kit; ProapoA-II)] ELISA kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    3.9 ng/mL-250 ng/mL
  • 灵敏度：
    0.98 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
  • 基因功能参考文献：
    1. Study reports a deterministic role for the B6 apoa2 gene polymorphism in respiratory rhythmogenesis. The in vivo inheritance pattern discloses a recessive effect of the B6 allele on the apnea phenotype, as the presence of both B6 alleles in the brain is required for transcript and trait expression; in contrast, apoa2 mRNA expression in the liver requires only one allele. PMID: 27756649
    2. The C-terminal APOA2F peptide might inhibit further extension of amyloid fibrils by blocking the active ends of nuclei. PMID: 25675489
    3. Data show that reticulum (ER) stress responses differed among tissues with extracellular AApoAII amyloid fibril deposition. PMID: 25545477
    4. In vivo, neither C57 nor FVB apoA-II protein levels are affected by the absence of apoE, while an apoE/apoA-I double deficiency results in a 50% decrease of plasma FVB apoA-II but results in undetectable levels of C57 apoA-II in the plasma. PMID: 24520415
    5. ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis. PMID: 21622630
    6. Exacerbated hepatitis is observed in ApoA-II-deficient mice, indicating that ApoA-II plays a suppressive role in concanavalin A-induced hepatitis under physiological conditions. PMID: 21300819
    7. Severe AApoAII deposits in the spleen, heart, skin, liver, and stomach were shown in the fish oil group compared with those in the butter and safflower oil groups (fish oil > butter > safflower oil group) PMID: 12562830
    8. Apoa2 injected into mice induced amyloidosis. PMID: 15063745
    9. tissue distribution, biochemical properties, and transmission of mouse type A AApoAII amyloid fibrils PMID: 15111306
    10. the presence of apoA-II on HDL particles inhibits the ability of endothelial lipase to influence the metabolism of HDL in vivo PMID: 16877778
    11. These studies indicate that increased levels of APOA2 protein lead to earlier and greater amyloid deposition and enhanced sensitivity to the transmission of amyloid fibrils in transgenic mice. PMID: 17468778
    12. ApoAII is efficiently reabsorbed in kidney proximal tubules in relation to its plasma concentration PMID: 17652309
    13. apoAII regulates the metabolism of triglyceride-rich lipoproteins, with HDL serving as a plasma reservoir of apoAII that is transferred to the triglyceride-rich lipoproteins in the same way as VLDL and chylomicrons acquire most of their apoCs from HDL PMID: 18160395
    14. These results are compatible with a role for apolipoproteins in lipid metabolism and transport in the developing lung in association with the sex difference in surfactant lipid synthesis. PMID: 19106236
    15. To understand the mechanism of amyloid fibril formation by apoA-II, we examined the polymerization of synthetic partial peptides of apoA-II in vitro. PMID: 19596087

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  • 相关疾病：
    Defects in Apoa2 are the cause of senescence accelerated mouse (SAM), the senile amyloid is a mutated apolipoprotein A-II.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Apolipoprotein A2 family
  • 组织特异性：
    Plasma.
  • 数据库链接：