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  4. Recombinant Mouse Apolipoprotein A-II (Apoa2)

Recombinant Mouse Apolipoprotein A-II (Apoa2)

  • 货号：
    CSB-YP001915MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001915MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001915MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001915MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001915MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Apoa2Apolipoprotein A-II; Apo-AII; ApoA-II; Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II; ProapoA-II)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-102
  • 氨基酸序列
    QADGPDM QSLFTQYFQS MTDYGKDLME KAKTSEIQSQ AKAYFEKTHE QLTPLVRSAG TSLVNFFSSL MNLEEKPAPA AK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
  • 基因功能参考文献：
    1. Study reports a deterministic role for the B6 apoa2 gene polymorphism in respiratory rhythmogenesis. The in vivo inheritance pattern discloses a recessive effect of the B6 allele on the apnea phenotype, as the presence of both B6 alleles in the brain is required for transcript and trait expression; in contrast, apoa2 mRNA expression in the liver requires only one allele. PMID: 27756649
    2. The C-terminal APOA2F peptide might inhibit further extension of amyloid fibrils by blocking the active ends of nuclei. PMID: 25675489
    3. Data show that reticulum (ER) stress responses differed among tissues with extracellular AApoAII amyloid fibril deposition. PMID: 25545477
    4. In vivo, neither C57 nor FVB apoA-II protein levels are affected by the absence of apoE, while an apoE/apoA-I double deficiency results in a 50% decrease of plasma FVB apoA-II but results in undetectable levels of C57 apoA-II in the plasma. PMID: 24520415
    5. ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis. PMID: 21622630
    6. Exacerbated hepatitis is observed in ApoA-II-deficient mice, indicating that ApoA-II plays a suppressive role in concanavalin A-induced hepatitis under physiological conditions. PMID: 21300819
    7. Severe AApoAII deposits in the spleen, heart, skin, liver, and stomach were shown in the fish oil group compared with those in the butter and safflower oil groups (fish oil > butter > safflower oil group) PMID: 12562830
    8. Apoa2 injected into mice induced amyloidosis. PMID: 15063745
    9. tissue distribution, biochemical properties, and transmission of mouse type A AApoAII amyloid fibrils PMID: 15111306
    10. the presence of apoA-II on HDL particles inhibits the ability of endothelial lipase to influence the metabolism of HDL in vivo PMID: 16877778
    11. These studies indicate that increased levels of APOA2 protein lead to earlier and greater amyloid deposition and enhanced sensitivity to the transmission of amyloid fibrils in transgenic mice. PMID: 17468778
    12. ApoAII is efficiently reabsorbed in kidney proximal tubules in relation to its plasma concentration PMID: 17652309
    13. apoAII regulates the metabolism of triglyceride-rich lipoproteins, with HDL serving as a plasma reservoir of apoAII that is transferred to the triglyceride-rich lipoproteins in the same way as VLDL and chylomicrons acquire most of their apoCs from HDL PMID: 18160395
    14. These results are compatible with a role for apolipoproteins in lipid metabolism and transport in the developing lung in association with the sex difference in surfactant lipid synthesis. PMID: 19106236
    15. To understand the mechanism of amyloid fibril formation by apoA-II, we examined the polymerization of synthetic partial peptides of apoA-II in vitro. PMID: 19596087

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  • 相关疾病：
    Defects in Apoa2 are the cause of senescence accelerated mouse (SAM), the senile amyloid is a mutated apolipoprotein A-II.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Apolipoprotein A2 family
  • 组织特异性：
    Plasma.
  • 数据库链接：

    KEGG: mmu:11807

    STRING: 10090.ENSMUSP00000005824

    UniGene: Mm.389209