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中文名称:小鼠Ⅰ型胶原C端肽(CTX-Ⅰ)酶联免疫试剂盒
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货号:CSB-E12782m
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规格:96T/48T
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价格:¥3600/¥2500
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其他:
产品详情
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产品描述:CTX-I (Ⅰ型胶原交联端肽,Type I collagen cross-linked C-telopeptide) CTX-I是一种胶原蛋白降解产物,其水平能够反映骨代谢状态。当骨组织发生破坏时,胶原蛋白被降解释放出CTX-I,血中CTX-I水平升高。CTX-I水平的升高可以作为骨质疏松和骨骼疾病的早期诊断指标和评估治疗效果的参考标志。j9九游会登录入口首页生物所提供的Mouse cross linked C-telopeptide of type I collagen (CTX-Ⅰ) ELISA Kit属于ELISA检测试剂盒,采用竞争法定量检测鼠血清、血浆、组织匀浆样本中的CTX-Ⅰ,其灵敏度为0.12 ng/ml,检测范围为0.23 ng/ml-15 ng/ml。
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别名:cross linked C-telopeptide of type 1 collagen (CTX-1),_x000D_cross linked C-telopeptide of type I collagen (CTX-I)
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缩写:CTX-Ⅰ
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种属:Mus musculus (Mouse)
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样本类型:serum, plasma, tissue homogenates.
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检测范围:0.23 ng/ml-15 ng/ml.
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灵敏度:0.12 ng/ml.
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Others
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测定原理:quantitative
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测定方法:Competitive
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
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线性度:
To assess the linearity of the assay, samples were spiked with high concentrations of mouse CTX-Ⅰ in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
Sample
Serum(n=4)
1:1
Average %
84
Range %
80-92
1:2
Average %
87
Range %
81-94
1:4
Average %
88
Range %
82-95
1:8
Average %
93
Range %
86-98
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回收率:
The recovery of mouse CTX-Ⅰ spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample Type
Average % Recovery
Range
Serum (n=5)
85
81-91
EDTA plasma (n=4)
87
82-93
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标准曲线:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ng/ml
OD1
OD2
Average
15
0.195
0.204
0.200
7.5
0.246
0.260
0.253
3.75
0.339
0.348
0.344
1.87
0.518
0.529
0.524
0.94
0.851
0.841
0.846
0.47
1.272
1.253
1.262
0.23
1.838
1.784
1.811
0
2.512
2.525
2.518
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数据处理:
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货期:3-5 working days
引用文献
- Stephanine Protects Against Osteoporosis by Suppressing Osteoclastogenesis via Inhibition of the RANKL—RANK Interaction T Liu, J Li, M Duan, Y Wang, Z Jiang,Journal of Cellular and Molecular Medicine,2024
- Altered post-fracture systemic bone loss in a mouse model of osteocyte dysfunction B Osipov, AJ Emami, HC Cunningham, S Orr,JBMR plus,2024
- FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism C Cheng, M Deng, C Cheng, H Wu, Y Wang,Journal of Orthopaedic Translation,2024
- Loss of ZC4H2, an Arthrogryposis Multiplex Congenita Associated Gene, Promotes Osteoclastogenesis in Mice L Zhu, L Zhang, J Cha, C Li, B Mao,Genes,2024
- PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging L Xie,Bone research,2024
- Oleanolic acid exerts bone anabolic effects via activation of osteoblastic 25-hydroxyvitamin D 1-alpha hydroxylase WX Yu,Biomedicine & pharmacotherapy,2024
- Activation of TAZ by XMU-MP-1 inhibits osteoclastogenesis and attenuates ovariectomy-induced cancellous bone loss X Li,Biochemical and biophysical research communications,2023
- Icariin, a phytoestrogen, exerts rapid estrogenic actions through crosstalk of estrogen receptors in osteoblasts KY Wong,Phytotherapy research,2023
- Cervical vertebrae for early bone loss evaluation in osteoporosis mouse models B Teng,Quantitative imaging in medicine and surgery,2023
- Simvastatin therapy in higher dosages deteriorates bone quality: Consistent evidence from population-wide patient data and interventional mouse studies M Leutner,Biomedicine & pharmacotherapy,2022
- Asiatic acid improves high-fat-diet-induced osteoporosis in mice via regulating SIRT1/FOXO1 signaling and inhibiting oxidative stress X Chen,Histology and histopathology,2022
- The effects of metformin and alendronate in attenuating bone loss and improving glucose metabolism in diabetes mellitus mice Q Zhou,Aging (Albany NY),2022
- Age-related accumulation of advanced oxidation protein products promotes osteoclastogenesis through disruption of redox homeostasis J Zhuang,cell death & disease,2021
- SIS3 suppresses osteoclastogenesis and ameliorates bone loss in ovariectomized mice by modulating Nox4-dependent reactive oxygen species Wenzheng Pan,Biochemical pharmacology,2021
- Conditional Knockout of PDK1 in Osteoclasts Suppressed Osteoclastogenesis and Ameliorated Prostate Cancer-Induced Osteolysis Y Zhang,Researchsquare,2021
- DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling B Zhang,Cell death & disease,2021
- Conditional knockout of the PDK‐1 gene in osteoblasts affects osteoblast differentiation and bone formation Y Bai,Journal of Cellular Physiology,2021
- Hydrogen sulfide protects against particle┸\induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening Liu L,FASEB,2020
- Catalpol suppresses osteoclastogenesis and attenuates osteoclast-derived bone resorption by modulating PTEN activity Meng J, et al,Biochemical Pharmacology,2019
- The emerging role of IMD 0354 on bone homeostasis by suppressing osteoclastogenesis and bone resorption, but without affecting bone formation Chen W, et al,Cell Death and Disease,2019
- The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling Xuewu Sun, et al,Redox Biology,2019
- A novel transgenic murine model with persistently brittle bones simulating osteogenesis imperfecta type I Yi Liu, et al,Bone,2019
- Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiency Monajemi M, et al,Journal of Leukocyte Biology,2019
- Absence of Dipeptidyl Peptidase 3 increases oxidative stress and causes bone loss Menale C, et al,Journal of Bone and Mineral Research,2019
- Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway Zheng L, et al,faseb journal,2019
- A novel anti-osteoporotic agent that protects against postmenopausal bone loss by regulating bone formation and bone resorption Yu-te Yang .et al,Life Sciences,2018
- Apolipoprotein E plays crucial roles in maintaining bone mass by promoting osteoblast differentiation via ERK1/2 pathway and by suppressing osteoclast differentiation via c-Fos, NFATc1, and NF-κB pathway TakaakiNoguchi.et al,Biochemical and Biophysical Research Communications,2018
- VEGF-C promotes the development of lymphatics in bone and bone loss Devon Hominick.et al,Elife. 2018,2018
- A Novel Diterpenoid Suppresses Osteoclastogenesis and Promotes Osteogenesis by Inhibiting Ifrd1-and IκBα-Mediated p65 Nuclear Translocation Xie, Zi\'ang.et al,Journal of Bone and Mineral Research ,2017
- Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-a-induced osteoclastogenesis and promoting osteoblastic differentiation in mice Noguchi T. et al,Biochem Biophys Res Commun,2015
- HYPOXIA-REPERFUSION AFFECTS OSTEOGENIC LINEAGE AND PROMOTES SICKLE CELL BONE DISEASE Dalle Carbonare L. et al,Blood,2015
- Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice Khorasani MS.et al,Arthritis Res Ther.,2015
- Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-a-induced osteoclastogenesis and promoting osteoblastic differentiation in mice Noguchi T. et al,Biochem Biophys Res Commun,2015
- Altered bone development in a mouse model of peripheral sensory nerve inactivation. Heffner MA et al,J Musculoskelet Neuronal Interact,2014
相关问答
What's the antibody information of this kit?
Coated anti. Goat against rabbit secondary antibody; Antigen Specific anti: Rabbit polyclonal antibody. Pls let me know if you have any further questions. Thank you.
靶点详情
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最新研究进展:Ⅰ型胶原交联脱氨酸肽(CTX-Ⅰ)是胶原蛋白分解产物之一,它被认为是骨吸收的生物标志物之一。CTX-Ⅰ的检测可以用于评估骨吸收水平,是一种广泛应用的临床诊断指标。最近的研究表明,CTX-Ⅰ还与一些非骨代谢方面的疾病有关,例如心血管疾病、糖尿病、肾脏疾病等。
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