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  4. Rat apolipoprotein A1 (Apo-A1) ELISA Kit

Rat apolipoprotein A1 (Apo-A1) ELISA Kit

  • 中文名称：
    大鼠载脂蛋白A1(Apo-A1)酶联免疫试剂盒
  • 货号：
    CSB-E08105r
  • 规格：
    96T/48T
  • 价格：
    ￥3900/￥2500
  • 其他：

产品详情

  • 产品描述：
        APOA1（载脂蛋白A1）是体内含量最丰富的载脂蛋白之一，在脂代谢中具有重要作用。APOA1主要负责高密度脂蛋白（HDL）的形成和调节。HDL是一种抗动脉粥样硬化物质，通过清除体内过多的胆固醇，防止胆固醇在血管内沉积而起到保护心血管健康的作用。APOA1在健康人体内的正常含量约为1.2-1.5 g/L。
        j9九游会登录入口首页生物所提供的Rat apolipoprotein A1 (Apo-A1) ELISA Kit属于ELISA检测试剂盒，采用双抗夹心法定量检测大鼠血清、血浆、组织匀浆样本中的APOA1，其灵敏度为0.14 ng/ml，检测范围为0.14 ng/ml-100 ng/ml。
     
  • 别名：
    Apoa1Apolipoprotein A-I ELISA kit; Apo-AI ELISA kit; ApoA-I ELISA kit; Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I ELISA kit; ProapoA-I)] ELISA kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Rattus norvegicus (Rat)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    0.14 ng/ml-100 ng/ml.
  • 灵敏度：
    0.14 ng/ml.
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cardiovascular
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

问答及客户评论

■ 常见问题解答
Q:


My samples are hemolyzed....could it be any problem with this samples when using the kits?

A:
Thanks for your inquiry. Serious hemolysis is not suitable for testing. You need to re-collect the samples.
If it is slightly hemolyzed, the impact is small and the samples can be used.
The sensitivity of this kit is relatively good, but we still advice you to use dual-wavelength detection to eliminate the impact.

靶点详情

  • 最新研究进展：
    APOA1是一种高密度脂蛋白(HDL)的主要成分，参与调节胆固醇代谢和清除血管内的胆固醇。最新研究表明，APOA1可以抑制乳腺癌的恶性转化和肺癌细胞的增殖，可能成为肿瘤治疗的新靶点。此外，APOA1水平与糖尿病、心血管疾病和肝病等多种疾病相关。
  • 功能：
    Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
  • 基因功能参考文献：
    1. both the route of administration and the formulation of apoA-I peptide significantly affect its pharmacokinetics and pharmacodynamics. PMID: 27881716
    2. ABCA1 is diminished and ABCG1 is increased by N-acetylcysteine, which counteracts the reduction in apo A-I-mediated cholesterol efflux PMID: 25305669
    3. Apolipoprotein A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes. PMID: 24814947
    4. ApoA-I may be a protective blood-borne factor involved in the remote ischemic preconditioning mechanism. PMID: 24155931
    5. It maintains cholesterol homeostasis. PMID: 24117066
    6. on neonatal rat ventricular cardiomyocytes, the aldosterone-dependent chronotropic effects of antiapoA-1 IgG involve the nongenomic activation of L-type calcium channels PMID: 22253414
    7. translocation of cholesterol and phospholipid into the cytosol is related to the apo A-I-mediated HDL assembly in astrocytes through functional association with caveolin-1 and a cyclosporin A-sensitive cyclophilin protein(s). PMID: 11773045
    8. ABCA1-dependent cholesterol mobilization to apoA-I increased new cholesterol synthesis, indicating depletion of the regulatory pool of hepatocyte cholesterol during HDL formation PMID: 14993246
    9. The association of CLPP with microtubules is mediated by caveolin-1, induced by apoA-I and regulates intracellular cholesterol trafficking for assembly of cellular lipids to apoA-I-HDL. PMID: 16606364
    10. Data show that a complex of apolipoprotein A-I and pregnenolone modulate the rate of protein biosynthesis in liver cells. PMID: 18457017
    11. ApoA-I reduced I/R-induced inflammatory responses, decreased renal microscopic damage and improved renal function. ApoA-I protects kidney from I/R injury by inhibiting inflammatory cytokines release and neutrophil infiltration and activation. PMID: 18535924

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Apolipoprotein A1/A4/E family
  • 组织特异性：
    Major protein of plasma HDL, also found in chylomicrons.
  • 数据库链接：