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Apoa1 Antibody

  • 货号：
    CSB-PA001913LA01RA
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat Heart tissue, Rat Liver tissue, Rat Spleen tissue, Rat Lung tissue, Rat Kidney tissue, Rat Brain tissue, Rat Stomach tissue
      All lanes: Apoa1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 31 kDa
      Observed band size: 31 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Rattus norvegicus (Rat) Apoa1 Polyclonal antibody
  • Uniprot No.：
    P04639
  • 基因名：
  • 别名：
    Apoa1Apolipoprotein A-I antibody; Apo-AI antibody; ApoA-I antibody; Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I antibody; ProapoA-I)] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Rat
  • 免疫原：
    Recombinant Rat Apoa1 protein (19-259AA)
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Apoa1 Antibody (CSB-PA001913LA01RA)，的标记方式是Non-conjugated。对于Apoa1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001913LB01RA Apoa1 Antibody, HRP conjugated ELISA
    FITC CSB-PA001913LC01RA Apoa1 Antibody, FITC conjugated
    Biotin CSB-PA001913LD01RA Apoa1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Antigen Affinity purified & Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
  • 基因功能参考文献：
    1. both the route of administration and the formulation of apoA-I peptide significantly affect its pharmacokinetics and pharmacodynamics. PMID: 27881716
    2. ABCA1 is diminished and ABCG1 is increased by N-acetylcysteine, which counteracts the reduction in apo A-I-mediated cholesterol efflux PMID: 25305669
    3. Apolipoprotein A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes. PMID: 24814947
    4. ApoA-I may be a protective blood-borne factor involved in the remote ischemic preconditioning mechanism. PMID: 24155931
    5. It maintains cholesterol homeostasis. PMID: 24117066
    6. on neonatal rat ventricular cardiomyocytes, the aldosterone-dependent chronotropic effects of antiapoA-1 IgG involve the nongenomic activation of L-type calcium channels PMID: 22253414
    7. translocation of cholesterol and phospholipid into the cytosol is related to the apo A-I-mediated HDL assembly in astrocytes through functional association with caveolin-1 and a cyclosporin A-sensitive cyclophilin protein(s). PMID: 11773045
    8. ABCA1-dependent cholesterol mobilization to apoA-I increased new cholesterol synthesis, indicating depletion of the regulatory pool of hepatocyte cholesterol during HDL formation PMID: 14993246
    9. The association of CLPP with microtubules is mediated by caveolin-1, induced by apoA-I and regulates intracellular cholesterol trafficking for assembly of cellular lipids to apoA-I-HDL. PMID: 16606364
    10. Data show that a complex of apolipoprotein A-I and pregnenolone modulate the rate of protein biosynthesis in liver cells. PMID: 18457017
    11. ApoA-I reduced I/R-induced inflammatory responses, decreased renal microscopic damage and improved renal function. ApoA-I protects kidney from I/R injury by inhibiting inflammatory cytokines release and neutrophil infiltration and activation. PMID: 18535924

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Apolipoprotein A1/A4/E family
  • 组织特异性：
    Major protein of plasma HDL, also found in chylomicrons.
  • 数据库链接：

    KEGG: rno:25081

    STRING: 10116.ENSRNOP00000065206

    UniGene: Rn.10308