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  4. AGO4 Antibody

AGO4 Antibody

  • 货号：
    CSB-PA950500
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA950500(AGO4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9HCK5
  • 基因名：
  • 别名：
    AGO4_HUMAN antibody; Argonaute4 antibody; eIF-2C 4 antibody; eIF2C 4 antibody; eif2c4 antibody; Eukaryotic translation initiation factor 2C 4 antibody; hAgo4 antibody; Protein argonaute-4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human AGO4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).
  • 基因功能参考文献：
    1. Chimeras with Ago4 N-terminal domains were defective in RISC activation & sometimes also in RNA loading. This highlights the pleiotropic role of the Ago N domain & emphasizes the unique position of human Ago4 within the Ago protein family. PMID: 23748378
    2. EIF2C4 protein is expressed in differentiating and terminally differentiated N-type cells more than in S- and I-type cells PMID: 19393748
  • 亚细胞定位：
    Cytoplasm, P-body.
  • 蛋白家族：
    Argonaute family, Ago subfamily
  • 数据库链接：

    HGNC: 18424

    OMIM: 607356

    KEGG: hsa:192670

    STRING: 9606.ENSP00000362306

    UniGene: Hs.744858