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AKR1A1 Antibody

  • 货号：
    CSB-PA967994
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from COLO205 cells and NIH-3T3 cells, using AKR1A1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AKR1A1 Polyclonal antibody
  • Uniprot No.：
    P14550
  • 基因名：
    AKR1A1
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human AKR1A1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Displays no reductase activity towards retinoids.
  • 基因功能参考文献：
    1. Data (including data from studies in knockout and transgenic mice) suggest that AKR1A1 in liver is involved in bioactivation of xenobiotic/carcinogen thioacetamide (TAA); Akr1a-/- knockout mice are resistant to TAA-induced liver injury/hepatotoxicity. PMID: 29763686
    2. prostaglandin F synthase activity of human and bovine aldo-keto reductases PMID: 23747692
    3. AKR1A1 could be involved in the metabolism of 4-hydroxynonenal and play a role in the resistance to oxidative stress PMID: 23643085
    4. AKR1A1 has little effect on the production of gamma-hydroxybutyrate PMID: 21276435
    5. structure of Apo R268A human aldose reductase reveals hinges and latches that control the kinetic mechanism PMID: 15769597
    6. the binding site residues deviating between ALR1 and ALR2 influence ligand affinity in a complex interplay, presumably involving changes of dynamic properties and differences of the solvation/desolvation balance upon ligand binding PMID: 18495158

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  • 亚细胞定位：
    Cytoplasm, cytosol. Apical cell membrane.
  • 蛋白家族：
    Aldo/keto reductase family
  • 组织特异性：
    Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
  • 数据库链接：

    HGNC: 380

    OMIM: 103830

    KEGG: hsa:10327

    STRING: 9606.ENSP00000312606

    UniGene: Hs.474584