AKR1A1 Antibody
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货号:CSB-PA082936
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规格:¥1100
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图片:
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其他:
产品详情
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Uniprot No.:P14550
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基因名:AKR1A1
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别名:AK1A1_HUMAN antibody; Akr1a1 antibody; Alcohol dehydrogenase [NADP+] antibody; Alcohol dehydrogenase antibody; Aldehyde reductase antibody; Aldo keto reductase family 1 member A1 (aldehyde reductase) antibody; Aldo-keto reductase family 1 member A1 antibody; ALDR1 antibody; ALR antibody; ARM antibody; DD3 antibody; MGC12529 antibody; MGC1380 antibody
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Synthetic peptide of Human AKR1A1
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,WB,IHC
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推荐稀释比:
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:50-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also i...显示更多
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基因功能参考文献:
- Data (including data from studies in knockout and transgenic mice) suggest that AKR1A1 in liver is involved in bioactivation of xenobiotic/carcinogen thioacetamide (TAA); Akr1a-/- knockout mice are resistant to TAA-induced liver injury/hepatotoxicity. PMID: 29763686
- prostaglandin F synthase activity of human and bovine aldo-keto reductases PMID: 23747692
- AKR1A1 could be involved in the metabolism of 4-hydroxynonenal and play a role in the resistance to oxidative stress PMID: 23643085
- AKR1A1 has little effect on the production of gamma-hydroxybutyrate PMID: 21276435
- structure of Apo R268A human aldose reductase reveals hinges and latches that control the kinetic mechanism PMID: 15769597
- the binding site residues deviating between ALR1 and ALR2 influence ligand affinity in a complex interplay, presumably involving changes of dynamic properties and differences of the solvation/desolvation balance upon ligand binding PMID: 18495158
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亚细胞定位:Cytoplasm, cytosol. Apical cell membrane.
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蛋白家族:Aldo/keto reductase family
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组织特异性:Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
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数据库链接:
HGNC: 380
OMIM: 103830
KEGG: hsa:10327
STRING: 9606.ENSP00000312606
UniGene: Hs.474584