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ANO9 Antibody

  • 中文名称：
    ANO9兔多克隆抗体
  • 货号：
    CSB-PA009384
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    A1A5B4
  • 基因名：
    ANO9
  • 别名：
    Ano9 antibody; ANO9_HUMAN antibody; Anoctamin-9 antibody; p53-induced gene 5 protein antibody; PIG5 antibody; TMEM16J antibody; TP53I5 antibody; Transmembrane protein 16J antibody; Tumor protein p53-inducible protein 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Anoctamin-9.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
  • 基因功能参考文献：
    1. ANO9 is a cation channel activated by a cAMP/PKA pathway and could play a role in intestine function. PMID: 29604966
    2. Our results showed that ANO9 is overexpressed in most pancreatic cancer cell lines tested and in B30% of tissue samples obtained from patients with pancreatic cancer. Moreover, high ANO9 expression was associated with increased proliferation of pancreatic cancer cells and poor survival in patients with pancreatic cancer. PMID: 29024940
    3. Suggest role for up-regulation of ANO9 in progression and metastasis of stage II and III colorectal carcinoma. PMID: 26317553
    4. Children with low 25-hydroxyvitamin D and TMEM16J rs7111432-AA or PKP3 rs10902158-GG polymorphisms were at increased risk for tuberculosis or death. PMID: 26872154
    5. These results demonstrate a strong association of single-nucleotide polymorphisms in the PKP3-SIGIRR-TMEM16J gene region and tuberculosis in discovery and validation cohorts. PMID: 22223854
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
  • 蛋白家族：
    Anoctamin family
  • 数据库链接：

    HGNC: 20679

    KEGG: hsa:338440

    STRING: 9606.ENSP00000332788

    UniGene: Hs.501622