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ARPP19 Antibody

  • 货号：
    CSB-PA348885LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA348885LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA348885LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ARPP19 Polyclonal antibody
  • Uniprot No.：
    P56211
  • 基因名：
    ARPP19
  • 别名：
    ARP19 antibody; ARP19_HUMAN antibody; ARPP-19 antibody; Arpp19 antibody; cAMP-regulated phosphoprotein 19 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human cAMP-regulated phosphoprotein 19 protein (2-105AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ARPP19 Antibody (CSB-PA348885LA01HU)，的标记方式是Non-conjugated。对于ARPP19 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA348885LB01HU ARPP19 Antibody, HRP conjugated ELISA
    FITC CSB-PA348885LC01HU ARPP19 Antibody, FITC conjugated
    Biotin CSB-PA348885LD01HU ARPP19 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.
  • 基因功能参考文献：
    1. Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A disinhibition. PMID: 28613156
    2. Study showed that ARPP-19 promoted both proliferation and metastasis of human glioma cells and the expression of ARPP-19 and CD147 in high-grade glioma was significantly higher than that in the low-grade glioma. PMID: 27380244
    3. Data show that micrRNA miR-320a directly targets cAMP-regulated phosphoprotein 19 (ARPP-19) and estrogen-related receptor gamma protein (ERRgamma) in breast cancer cell lines. PMID: 25736597
    4. ARPP-19 may play a role in HCC pathogenesis through regulating cell proliferation. PMID: 25547487
    5. ARPP19 gene expression is decreased in follicular variant of papillary thyroid carcinoma. PMID: 21509594
    6. Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease. PMID: 11771749

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Endosulfine family
  • 数据库链接：

    HGNC: 16967

    OMIM: 605487

    KEGG: hsa:10776

    STRING: 9606.ENSP00000249822

    UniGene: Hs.512908