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ARSG Antibody

  • 货号：
    CSB-PA008275
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of mouse cells using Arylsulfatase G Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q96EG1
  • 基因名：
    ARSG
  • 别名：
    Arsg antibody; ARSG_HUMAN antibody; Arylsulfatase G antibody; Arylsulfatase G precursor antibody; ASG antibody; KIAA1001 antibody; PRO1777 antibody; UNQ839 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Arylsulfatase G.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.
  • 基因功能参考文献：
    1. This study provide further support for a role of ARSG variants in task-specific dystonia, especially writer's cramp. PMID: 25825126
    2. Genome-wide significance with musician's dystonia was observed for an intronic variant in the arylsulfatase G (ARSG) gene (rs11655081; P = 3.95 x 10(-9) ; odds ratio [OR], 4.33; 95% confidence interval [CI], 2.66-7.05). PMID: 24375517
    3. ARSG is differentially expressed, processed, and transported in tissues involving a membrane-associated pre-lysosomal precursor. PMID: 25135642
    4. Consistent genetic factors for ATP2B1, CSK, ARSG and CSMD1 were present, which have been shown to be associated with high blood pressure and hypertension in two Korean cohorts. PMID: 19960030
    5. molecular cloning and biochemical characterization of Arylsulfatase G [ARSG] PMID: 12461688
    6. Arylsulfatase G is a novel lysosomal sulfatase and its expression is tissue-specific with highest expression in liver, kidney, and pancreas PMID: 18283100

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  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    Sulfatase family
  • 组织特异性：
    Widely expressed, with very low expression in brain, lung, heart and skeletal muscle.
  • 数据库链接：

    HGNC: 24102

    OMIM: 610008

    KEGG: hsa:22901

    STRING: 9606.ENSP00000407193

    UniGene: Hs.437249