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ASB10 Antibody

  • 货号：
    CSB-PA691151
  • 规格：
    ￥1100
  • 图片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: CSB-PA691151(ASB10 Antibody) at dilution 1/1650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q8WXI3
  • 基因名：
    ASB10
  • 别名：
    ASB10Ankyrin repeat and SOCS box protein 10 antibody; ASB-10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human ASB10
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • 基因功能参考文献：
    1. Variants in ASB10 were found to be significantly associated with sporadic POAG in the Pakistani population PMID: 26713451
    2. These findings suggested that the genes in the GLC1F locus may be associated with the pathogenesis of normal tension glaucoma. PMID: 20309402
    3. ASB10 may play a role in ubiquitin-mediated degradation pathways in tabecular meshwork cells. PMID: 23901248
    4. non-synonymous mutations in ASB10 do not cause Mendelian forms of primary open angle glaucoma PMID: 22798626
    5. Variants in ASB10 are associated with open-angle glaucoma. PMID: 22156576

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  • 相关疾病：
    Glaucoma 1, open angle, F (GLC1F)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=In the ciliary body, it is detected in the cytoplasm and perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of retinal ganglion cells.
  • 蛋白家族：
    Ankyrin SOCS box (ASB) family
  • 组织特异性：
    Expressed in the eye. The highest expression is observed in the iris, with moderate levels in the trabecular meshwork (TM), the lamina, and the optic nerve; slightly lower levels in the ciliary body, retina, and choroid; and very low levels in the lens.
  • 数据库链接：

    HGNC: 17185

    OMIM: 603383

    KEGG: hsa:136371

    STRING: 9606.ENSP00000391137

    UniGene: Hs.647081