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  4. Recombinant Human Ankyrin repeat and SOCS box protein 10 (ASB10)

Recombinant Human Ankyrin repeat and SOCS box protein 10 (ASB10)

  • 中文名称：
    Recombinant Human Ankyrin repeat and SOCS box protein 10(ASB10),Yeast
  • 货号：
    CSB-YP845168HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin repeat and SOCS box protein 10(ASB10),Yeast
  • 货号：
    CSB-EP845168HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin repeat and SOCS box protein 10(ASB10),Yeast
  • 货号：
    CSB-EP845168HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin repeat and SOCS box protein 10(ASB10),Yeast
  • 货号：
    CSB-BP845168HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin repeat and SOCS box protein 10(ASB10),Yeast
  • 货号：
    CSB-MP845168HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ASB10
  • Uniprot No.：
  • 别名：
    ASB10Ankyrin repeat and SOCS box protein 10; ASB-10
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-467
  • 氨基酸序列
    MLMSWSPEEC KGQGEPLDDR HPLCARLVEK PSRGSEEHLK SGPGPIVTRT ASGPALAFWQ AVLAGDVGCV SRILADSSTG LAPDSVFDTS DPERWRDFRF NIRALRLWSL TYEEELTTPL HVAASRGHTE VLRLLLRRRA RPDSAPGGRT ALHEACAAGH TACVHVLLVA GADPNIADQD GKRPLHLCRG PGTLECAELL LRFGARVDGR SEEEEETPLH VAARLGHVEL ADLLLRRGAC PDARNAEGWT PLLAACDVRC QSITDAEATT ARCLQLCSLL LSAGADADAA DQDKQRPLHL ACRRGHAAVV ELLLSCGVSA NTMDYGGHTP LHCALQGPAA ALAQSPEHVV RALLNHGAVR VWPGALPKVL ERWSTCPRTI EVLMNTYSVV QLPEEAVGLV TPETLQKHQR FYSSLFALVR QPRSLQHLSR CALRSHLEGS LPQALPRLPL PPRLLRYLQL DFEGVLY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • 基因功能参考文献：
    1. Variants in ASB10 were found to be significantly associated with sporadic POAG in the Pakistani population PMID: 26713451
    2. These findings suggested that the genes in the GLC1F locus may be associated with the pathogenesis of normal tension glaucoma. PMID: 20309402
    3. ASB10 may play a role in ubiquitin-mediated degradation pathways in tabecular meshwork cells. PMID: 23901248
    4. non-synonymous mutations in ASB10 do not cause Mendelian forms of primary open angle glaucoma PMID: 22798626
    5. Variants in ASB10 are associated with open-angle glaucoma. PMID: 22156576

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  • 相关疾病：
    Glaucoma 1, open angle, F (GLC1F)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=In the ciliary body, it is detected in the cytoplasm and perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of retinal ganglion cells.
  • 蛋白家族：
    Ankyrin SOCS box (ASB) family
  • 组织特异性：
    Expressed in the eye. The highest expression is observed in the iris, with moderate levels in the trabecular meshwork (TM), the lamina, and the optic nerve; slightly lower levels in the ciliary body, retina, and choroid; and very low levels in the lens.
  • 数据库链接：

    HGNC: 17185

    OMIM: 603383

    KEGG: hsa:136371

    STRING: 9606.ENSP00000391137

    UniGene: Hs.647081