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ATAD5 Antibody

  • 中文名称：
    ATAD5兔多克隆抗体
  • 货号：
    CSB-PA119643
  • 规格：
    ￥1100
  • 图片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: CSB-PA119643(ATAD5 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q96QE3
  • 基因名：
    ATAD5
  • 别名：
    ATAD5 antibody; ATAD5_HUMAN antibody; ATPase family AAA domain containing 5 antibody; ATPase family AAA domain-containing protein 5 antibody; C17orf41 antibody; chromosome fragility associated gene 1 antibody; Chromosome fragility-associated gene 1 protein antibody; ELG1 antibody; Enhanced level of genomic instability 1 homolog antibody; FRAG1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human ATAD5
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.
  • 基因功能参考文献：
    1. Report rare ATAD5 missense mutations may contribute to genetic susceptibility breast cancer and epithelial ovarian carcinoma. PMID: 27045477
    2. s discuss many functions of Elg1 protein as embryonic lethal when lost in mice, as a tumor suppressor in mice and humans, interacts with human Fanconi Anemia pathway and may contribute to some of the phenotypes associated with neurofibromatosis. [Review] PMID: 25795125
    3. Elg1 has an important role in maintaining chromosome integrity by regulating PCNA levels on chromatin, thereby acting as a PCNA unloading factor. PMID: 23937667
    4. ATAD5 regulates the cycle of DNA replication factories, probably through its PCNA-unloading activity. PMID: 23277426
    5. loss-of-function mutations in mammalian Atad5 are sufficient to cause genomic instability and tumorigenesis. PMID: 21901109
    6. Studies indicate that USP1 and ELG1 as regulators of PCNA ubiquitylation. PMID: 21640107
    7. Human ELG1 protein is stabilized and localized to form foci at sites of stalled DNA replications that are different from DNA double strand breaks foci. PMID: 19755857
    8. The Frag1 signal pathway, by linking replication stress surveillance with apoptosis induction, plays a central role in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. PMID: 15983387

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    AAA ATPase family
  • 数据库链接：

    HGNC: 25752

    OMIM: 609534

    KEGG: hsa:79915

    STRING: 9606.ENSP00000313171

    UniGene: Hs.528902