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AZIN1 Antibody

  • 中文名称：
    AZIN1兔多克隆抗体
  • 货号：
    CSB-PA002484LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: AZIN1 antibody at 4µg/ml
      Lane 1: Mouse liver tissue
      Lane 2: PC-3 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 50 kDa
      Observed band size: 50 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA002484LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA002484LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AZIN1 Polyclonal antibody
  • Uniprot No.：
    O14977
  • 基因名：
  • 别名：
    Antizyme inhibitor 1 antibody; AZI antibody; Azin1 antibody; AZIN1_HUMAN antibody; OAZI antibody; OAZIN antibody; ODC1L antibody; Ornithine decarboxylase antizyme inhibitor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Antizyme inhibitor 1 protein (101-400AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AZIN1 Antibody (CSB-PA002484LA01HU)，的标记方式是Non-conjugated。对于AZIN1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA002484LB01HU AZIN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA002484LC01HU AZIN1 Antibody, FITC conjugated
    Biotin CSB-PA002484LD01HU AZIN1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.
  • 基因功能参考文献：
    1. Using high-resolution (1)H-NMR spectroscopy, we demonstrated that a long-looped quadruplex in the AZIN1 mRNA co-exists in salt-dependent equilibria with a hairpin structure. PMID: 30063205
    2. e in vivo experiment confirmed that this RNA editing confers higher capacity of tumor migration as well. In conclusion, antizyme inhibitor 1 RNA editing and its involvement in tumorigenesis of non-small-cell lung cancer pave a new way for potential clinical management of non-small-cell lung cancer. PMID: 28849733
    3. AzI1 fulfils an essential regulatory function in polyamine homeostasis and cell proliferation. PMID: 25813938
    4. Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN). PMID: 26305948
    5. This study also suggests that highly expressed AZI may be partly responsible for increased ODC activity and cellular transformation. PMID: 15670771
    6. edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1 PMID: 23291631
    7. minor allelic SNP variant in 12th exon of AZIN1 associated with slower rates of fibrosis progression favors expression of novel splice form, AZIN1 SV2, that inhibits expression of fibrogenic genes in hepatic stellate cells. PMID: 21837750
    8. AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC and AZI and inhibition of their function. PMID: 21931692
    9. SNP rs2679757 in the AZIN1 gene is associated with the risk of HBV-related liver cirrhosis in Chinese patients. PMID: 21586232
    10. Decreased ornithine decarboxylase is associated with prostate cancer. PMID: 20215859

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Orn/Lys/Arg decarboxylase class-II family, ODC antizyme inhibitor subfamily
  • 组织特异性：
    Expressed in liver.
  • 数据库链接：

    HGNC: 16432

    OMIM: 607909

    KEGG: hsa:51582

    STRING: 9606.ENSP00000321507

    UniGene: Hs.459106