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AZIN1 Antibody

  • 货号：
    CSB-PA002484GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O14977
  • 基因名：
  • 别名：
    Antizyme inhibitor 1 antibody; AZI antibody; Azin1 antibody; AZIN1_HUMAN antibody; OAZI antibody; OAZIN antibody; ODC1L antibody; Ornithine decarboxylase antizyme inhibitor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human AZIN1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.
  • 基因功能参考文献：
    1. Using high-resolution (1)H-NMR spectroscopy, we demonstrated that a long-looped quadruplex in the AZIN1 mRNA co-exists in salt-dependent equilibria with a hairpin structure. PMID: 30063205
    2. e in vivo experiment confirmed that this RNA editing confers higher capacity of tumor migration as well. In conclusion, antizyme inhibitor 1 RNA editing and its involvement in tumorigenesis of non-small-cell lung cancer pave a new way for potential clinical management of non-small-cell lung cancer. PMID: 28849733
    3. AzI1 fulfils an essential regulatory function in polyamine homeostasis and cell proliferation. PMID: 25813938
    4. Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN). PMID: 26305948
    5. This study also suggests that highly expressed AZI may be partly responsible for increased ODC activity and cellular transformation. PMID: 15670771
    6. edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1 PMID: 23291631
    7. minor allelic SNP variant in 12th exon of AZIN1 associated with slower rates of fibrosis progression favors expression of novel splice form, AZIN1 SV2, that inhibits expression of fibrogenic genes in hepatic stellate cells. PMID: 21837750
    8. AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC and AZI and inhibition of their function. PMID: 21931692
    9. SNP rs2679757 in the AZIN1 gene is associated with the risk of HBV-related liver cirrhosis in Chinese patients. PMID: 21586232
    10. Decreased ornithine decarboxylase is associated with prostate cancer. PMID: 20215859

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Orn/Lys/Arg decarboxylase class-II family, ODC antizyme inhibitor subfamily
  • 组织特异性：
    Expressed in liver.
  • 数据库链接：

    HGNC: 16432

    OMIM: 607909

    KEGG: hsa:51582

    STRING: 9606.ENSP00000321507

    UniGene: Hs.459106