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BATF2 Antibody

  • 货号：
    CSB-PA822685LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA822685LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA822685LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BATF2 Polyclonal antibody
  • Uniprot No.：
    Q8N1L9
  • 基因名：
    BATF2
  • 别名：
    BATF2Basic leucine zipper transcriptional factor ATF-like 2 antibody; B-ATF-2 antibody; Suppressor of AP-1 regulated by IFN antibody; SARI antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Basic leucine zipper transcriptional factor ATF-like 2 protein (1-189AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BATF2 Antibody (CSB-PA822685LA01HU)，的标记方式是Non-conjugated。对于BATF2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA822685LB01HU BATF2 Antibody, HRP conjugated ELISA
    FITC CSB-PA822685LC01HU BATF2 Antibody, FITC conjugated
    Biotin CSB-PA822685LD01HU BATF2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter.
  • 基因功能参考文献：
    1. BATF2 gene was modulated after treatment with zebularine and was a poor prognostic marker, since its low levels were correlated with relapse and a poor prognosis for medulloblastoma patients. PMID: 27785591
    2. Gain- and loss-of-function studies uncovered a role for Batf2 in myeloid differentiation in both murine and human systems. We thus demonstrate that chronic infection can deplete HSPCs and identify BATF2 as a mediator of infection-induced HSPC terminal differentiation PMID: 27926863
    3. Our findings expanded the understanding of the role of BATF2 in tumors, and also suggested a potential of using BATF2 as a therapeutic target to hinder bevacizumab induced epithelial-mesenchymal transition in glioblastoma. PMID: 28739720
    4. BATF2 may exert selective pressure on the recombination machinery via a repetitive motif-based mechanism for the maintenance of heterochromatin stability. PMID: 26977016
    5. Batf2 has a role in infectious diseases and cancer PMID: 26376615
    6. Results demonstrate that SARI is a novel target gene of glucocorticoid receptor, and the upregulation of SARI plays an important role in dexamethasone's killing effect on B lymphoma cells. PMID: 26808579
    7. Suggest that SARI might play an important role in the occurrence and development of prostate cancer. IFN-beta might inhibit the growth of prostate cancer and promote cellular apoptosis by inducing the expression of SARI. PMID: 26339361
    8. In conclusion, as a tumor suppressor, BATF2 serves as a prognostic biomarker of esophageal squamous cell carcinoma and it may be a potential therapeutic target for ESCC treatment. PMID: 26135942
    9. these findings indicate that BATF2 status could be served as a potential biomarker to predict prognosis in colorectal cancer PMID: 26022579
    10. these novel findings suggest that BATF2, a tumor suppressor gene, is a potent negative regulator of HGF/MET signaling in colorectal cancer PMID: 25762344
    11. BATF2 plays a tumor-suppressor role in the development of oral tongue squamous cell carcinoma and BATF2 may serve as a prognostic biomarker and potential therapeutic target for this disease. PMID: 24252932
    12. SARI expression may predict a poor prognosis in non-small cell lung patients, and SARI may serve as a prognostic biomarker and potential therapeutic target for lung cancer. PMID: 24133583
    13. MDA-7/IL-24 has a role in cancer-specific apoptosis through SARI induction PMID: 24282278
    14. Loss of SARI expression initiates epithelial-to-mesenchymal transition (EMT), which is visualized by repression of E-cadherin and up-regulation of vimentin in lung adenocarcinoma cell lines and in clinical lung adenocarcinoma specimens. PMID: 23049725
    15. BCR-ABL mediates the down-regulation of SARI mRNA expression in K562 cells. PMID: 21867603
    16. Data suggest that SARI as a potential therapeutic target in CML. PMID: 21892628
    17. Decreased expression of BATF2 is associated with hepatocellular carcinoma. PMID: 20473897
    18. Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1. PMID: 20531301

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family
  • 数据库链接：

    HGNC: 25163

    OMIM: 614983

    KEGG: hsa:116071

    STRING: 9606.ENSP00000301887

    UniGene: Hs.124840