Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Basic leucine zipper transcriptional factor ATF-like 2 (BATF2)

Recombinant Human Basic leucine zipper transcriptional factor ATF-like 2 (BATF2)

  • 中文名称：
    Recombinant Human Basic leucine zipper transcriptional factor ATF-like 2(BATF2),Yeast
  • 货号：
    CSB-YP822685HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Basic leucine zipper transcriptional factor ATF-like 2(BATF2),Yeast
  • 货号：
    CSB-EP822685HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Basic leucine zipper transcriptional factor ATF-like 2(BATF2),Yeast
  • 货号：
    CSB-EP822685HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Basic leucine zipper transcriptional factor ATF-like 2(BATF2),Yeast
  • 货号：
    CSB-BP822685HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Basic leucine zipper transcriptional factor ATF-like 2(BATF2),Yeast
  • 货号：
    CSB-MP822685HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BATF2
  • Uniprot No.：
  • 别名：
    BATF2Basic leucine zipper transcriptional factor ATF-like 2; B-ATF-2; Suppressor of AP-1 regulated by IFN; SARI
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-274
  • 氨基酸序列
    MHLCGGNGLL TQTDPKEQQR QLKKQKNRAA AQRSRQKHTD KADALHQQHE SLEKDNLALR KEIQSLQAEL AWWSRTLHVH ERLCPMDCAS CSAPGLLGCW DQAEGLLGPG PQGQHGCREQ LELFQTPGSC YPAQPLSPGP QPHDSPSLLQ CPLPSLSLGP AVVAEPPVQL SPSPLLFASH TGSSLQGSSS KLSALQPSLT AQTAPPQPLE LEHPTRGKLG SSPDNPSSAL GLARLQSREH KPALSAATWQ GLVVDPSPHP LLAFPLLSSA QVHF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter.
  • 基因功能参考文献：
    1. BATF2 gene was modulated after treatment with zebularine and was a poor prognostic marker, since its low levels were correlated with relapse and a poor prognosis for medulloblastoma patients. PMID: 27785591
    2. Gain- and loss-of-function studies uncovered a role for Batf2 in myeloid differentiation in both murine and human systems. We thus demonstrate that chronic infection can deplete HSPCs and identify BATF2 as a mediator of infection-induced HSPC terminal differentiation PMID: 27926863
    3. Our findings expanded the understanding of the role of BATF2 in tumors, and also suggested a potential of using BATF2 as a therapeutic target to hinder bevacizumab induced epithelial-mesenchymal transition in glioblastoma. PMID: 28739720
    4. BATF2 may exert selective pressure on the recombination machinery via a repetitive motif-based mechanism for the maintenance of heterochromatin stability. PMID: 26977016
    5. Batf2 has a role in infectious diseases and cancer PMID: 26376615
    6. Results demonstrate that SARI is a novel target gene of glucocorticoid receptor, and the upregulation of SARI plays an important role in dexamethasone's killing effect on B lymphoma cells. PMID: 26808579
    7. Suggest that SARI might play an important role in the occurrence and development of prostate cancer. IFN-beta might inhibit the growth of prostate cancer and promote cellular apoptosis by inducing the expression of SARI. PMID: 26339361
    8. In conclusion, as a tumor suppressor, BATF2 serves as a prognostic biomarker of esophageal squamous cell carcinoma and it may be a potential therapeutic target for ESCC treatment. PMID: 26135942
    9. these findings indicate that BATF2 status could be served as a potential biomarker to predict prognosis in colorectal cancer PMID: 26022579
    10. these novel findings suggest that BATF2, a tumor suppressor gene, is a potent negative regulator of HGF/MET signaling in colorectal cancer PMID: 25762344
    11. BATF2 plays a tumor-suppressor role in the development of oral tongue squamous cell carcinoma and BATF2 may serve as a prognostic biomarker and potential therapeutic target for this disease. PMID: 24252932
    12. SARI expression may predict a poor prognosis in non-small cell lung patients, and SARI may serve as a prognostic biomarker and potential therapeutic target for lung cancer. PMID: 24133583
    13. MDA-7/IL-24 has a role in cancer-specific apoptosis through SARI induction PMID: 24282278
    14. Loss of SARI expression initiates epithelial-to-mesenchymal transition (EMT), which is visualized by repression of E-cadherin and up-regulation of vimentin in lung adenocarcinoma cell lines and in clinical lung adenocarcinoma specimens. PMID: 23049725
    15. BCR-ABL mediates the down-regulation of SARI mRNA expression in K562 cells. PMID: 21867603
    16. Data suggest that SARI as a potential therapeutic target in CML. PMID: 21892628
    17. Decreased expression of BATF2 is associated with hepatocellular carcinoma. PMID: 20473897
    18. Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1. PMID: 20531301

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family
  • 数据库链接：

    HGNC: 25163

    OMIM: 614983

    KEGG: hsa:116071

    STRING: 9606.ENSP00000301887

    UniGene: Hs.124840