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BCDIN3D Antibody

  • 货号：
    CSB-PA767206LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BCDIN3D Polyclonal antibody
  • Uniprot No.：
    Q7Z5W3
  • 基因名：
    BCDIN3D
  • 别名：
    BCDIN3 domain containing antibody; BCDIN3 domain-containing protein antibody; BCDIN3D antibody; BN3D2_HUMAN antibody; Probable methyltransferase BCDIN3D antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pre-miRNA 5'-monophosphate methyltransferase protein (1-292AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BCDIN3D Antibody (CSB-PA767206LA01HU)，的标记方式是Non-conjugated。对于BCDIN3D Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA767206LB01HU BCDIN3D Antibody, HRP conjugated ELISA
    FITC CSB-PA767206LC01HU BCDIN3D Antibody, FITC conjugated
    Biotin CSB-PA767206LD01HU BCDIN3D Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.
  • 基因功能参考文献：
    1. BCDIN3D might serve as an important prognostic factor for triple-negative breast cancer PMID: 27259993
    2. BCDIN3D acts as a cytoplasmic tRNAHis-specific 5-methylphosphate capping enzyme. PMID: 28119416
    3. Human BCDIN3D monomethylates the 5'-monophosphate of cytoplasmic tRNAHis in vitro. In BCDN3D-knockout cells, established byCRISPR/Cas9 editing, the methyl moiety at the 5'-monophosphate of cytoplasmic tRNAHis is lost, and the exogenous expression of BCDIN3D in the knockout cells restores the modification in cytoplasmic tRNAHis. PMID: 28119416
    4. BCDIN3D depletion leads to lower pre-miR-145 and concomitantly increased mature miR-145 levels in breast cancer cells, which suppresses their tumorigenic phenotypes. PMID: 23063121
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Methyltransferase superfamily
  • 数据库链接：

    HGNC: 27050

    KEGG: hsa:144233

    STRING: 9606.ENSP00000335201

    UniGene: Hs.142736