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BHLHE41 Antibody

  • 中文名称：
    BHLHE41兔多克隆抗体
  • 货号：
    CSB-PA060142
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9C0J9
  • 基因名：
    BHLHE41
  • 别名：
    Basic helix-loop-helix domain containing class B3 antibody; BHE41_HUMAN antibody; bHLH protein DEC2 antibody; bHLHB3 antibody; bHLHe41 antibody; Class B basic helix loop helix protein 3 antibody; Class B basic helix-loop-helix protein 3 antibody; Class E basic helix-loop-helix protein 41 antibody; DEC2 antibody; Differentially expressed in chondrocytes protein 2 antibody; Enhancer of split and hairy related protein 1 antibody; Enhancer-of-split and hairy-related protein 1 antibody; hDEC2 antibody; Moderately similar to basic-helix loop helix protein M.musculus antibody; SHARP-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human 40879.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11.
  • 基因功能参考文献：
    1. We validated DEC2 gene as a direct target of miR-873 which could reverse the repressive effects of miR-873 on esophageal cancer cell. PMID: 29890466
    2. Knockdown of DEC2 resulted in a significant (26.7%) reduction of VEGF expression in MIO-M1 cells under hypoxia-mimicking conditions induced by DFO (P < .05). Levels of HIF1alpha protein were also reduced significantly, by 60.2%, in MIO-M1 cells treated with siRNA against the DEC2 gene (P < .05). Moreover, HIF1alpha levels showed a significant (2.5-fold) increase in MIO-M1 cells overexpressing DEC2 (P < .05). PMID: 30250985
    3. Mutation in DCE2 gene is associated with short sleep behavioral trait. PMID: 29531056
    4. It has been concluded that the renal cell carcinoma risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 expression which, in turn, induces IL-11, a member of the IL-6 cytokine family. PMID: 27384883
    5. venous levels lower in preeclampsia than in normal pregnancy PMID: 27845885
    6. The renal cell cancers associated polymorphic HIF-binding site at chromosome 12p12.1 regulates BHLHE41 expression. PMID: 28715484
    7. Findings suggest that basic helix-loop-helix family, member e41 protein (DEC2) suppresses cell cycle progression of the mesenchymal cells. PMID: 27430159
    8. DEC1, at least partly, exerted a pro-apoptotic effect, whereas DEC2 exerted an anti-apoptotic effect in paclitaxel-induced apoptosis of human prostate cancer cells. PMID: 27840924
    9. the present study indicated that SHARP1 acts as a tumor suppressor in thyroid cancer and that its downregulation may contribute to the proliferation, migration and invasion of thyroid cancer cells through mechanisms possibly involving HIF1alpha PMID: 27121679
    10. Study found that DEC2 was a direct target of miR-138. PMID: 27095063
    11. DEC2 is aberrantly expressed in rheumatoid arthritis tissue, it is induced by TNFalpha and not only affects the expression of genes belonging to molecular clock but also significantly impacts on the expression of IL-1beta as well as other inflammatory genes. PMID: 26710124
    12. BHLHE40/41 are promising markers to predict the aggressiveness of each Endometrial Neoplasm case and that molecular targeting strategies involving BHLHE40/41 and SP1 may effectively regulate Endometrial Neoplasm progression. PMID: 26391953
    13. DEC2 facilitates HIF-1alpha stabilization and promotes HIF-1 activation in osteosarcoma. PMID: 25884381
    14. DEC2 participates in hypoxia-induced cell proliferation by functioning as a target gene of the PI3K/Akt signaling pathway and regulating the expression of c-Myc. PMID: 25524285
    15. SHARP1 interacted with HIF-1alpha physically. PMID: 24918449
    16. Data suggest that SHARP1 plays a critical role in tumorigenesis and acquisition of the metastatic phenotype in endometrial cancer. PMID: 24997474
    17. DEC2 regulates cellular function by modulating the expression of Twist1 PMID: 25446074
    18. BHLHE41 mutations reduce total sleep while maintaining NREM sleep and provide resistance to the effects of sleep loss; mutations that affect sleep also modify the normal inhibition of BHLHE41 of CLOCK/BMAL1 transactivation PMID: 25083013
    19. we find high frequency of RAS mutations in t(6;11)(q27;q23) pediatric AML and are the first to report a unique and significant differential overexpression of BHLHB3 in these patients. PMID: 24561520
    20. GLI1 expression was immunohistochemically related positively with BHLHE41 and inversely with MLH1 in PDAC cells and precancerous lesions of the pancreas. PMID: 24165159
    21. Sumoylation of Sharp-1 exerts an impact on chromatin structure and transcriptional repression of muscle gene expression through recruitment of G9a. PMID: 23637228
    22. DEC2 regulates apoptosis in oral cancer cells via regulation of pro-apoptotic factor Bim expression PMID: 22572381
    23. SHARP1 is required, and sufficient, to limit expression of HIF-target genes PMID: 22801492
    24. results suggest that DEC2 periodically represses the promoter activity of CYP2D6, resulting in its circadian expression in serum-shocked cells PMID: 22355045
    25. DEC2 has anti-apoptotic effects on the paclitaxel-induced apoptosis in human breast cancer MCF-7 cells. PMID: 21327324
    26. demonstrated DEC2 expression in response to the treatment with polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA, in cultured human mesangial cells PMID: 21129405
    27. a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes PMID: 16287852
    28. DEC1 and DEC2 may play a crucial role in the adaptation to hypoxia PMID: 12354771
    29. Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family. [dec1] PMID: 12397359
    30. DEC1-mediated repression on the expression of DEC2 PMID: 12624110
    31. role of the BHLHB3 protein as a tumor suppressor for lung cancer. PMID: 18223678
    32. MLH1 is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. PMID: 18345027
    33. DEC1, along with DEC2, plays a role in the finer regulation and robustness of the molecular clock CLOCK/BMAL1 PMID: 18411297
    34. study identified a mutation, P385R, in DEC2 associated with a short sleep phenotype; activity profiles & sleep recordings of transgenic mice carrying this mutation showed increased vigilance time and less sleep time than control mice PMID: 19679812

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.
  • 数据库链接：

    HGNC: 16617

    OMIM: 606200

    KEGG: hsa:79365

    STRING: 9606.ENSP00000242728

    UniGene: Hs.177841