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BORA Antibody

  • 货号：
    CSB-PA750873LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, SH-SY5Y whole cell lysate
      All lanes: BORA antibody at 4.8µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 62, 54 kDa
      Observed band size: 62 kDa
    • IHC image of CSB-PA750873LA01HU diluted at 1:300 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BORA Polyclonal antibody
  • Uniprot No.：
    Q6PGQ7
  • 基因名：
    BORA
  • 别名：
    Aurora borealis antibody; bora antibody; bora; aurora kinase A activator antibody; BORA_HUMAN antibody; C13orf34 antibody; Chromosome 13 open reading frame 34 antibody; FLJ22624 antibody; HsBora antibody; Protein aurora borealis antibody; RP11-342J4.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein aurora borealis protein (178-312AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BORA Antibody (CSB-PA750873LA01HU)，的标记方式是Non-conjugated。对于BORA Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA750873LB01HU BORA Antibody, HRP conjugated ELISA
    FITC CSB-PA750873LC01HU BORA Antibody, FITC conjugated
    Biotin CSB-PA750873LD01HU BORA Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for the activation of AURKA at the onset of mitosis.
  • 基因功能参考文献：
    1. our findings demonstrated that Bora was overexpressed and served as an independent biomarker for poor prognosis in multiple adenocarcinomas. PMID: 28402276
    2. the mechanism of Plk1 activation and the potential role of Bora phosphorylation by Cdk1, is reported. PMID: 27831827
    3. These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry. PMID: 27068477
    4. Bora was found to play a significant role in radiosensitivity through the regulation of MDC1 and DNA repair. PMID: 25742493
    5. Activation of Plk1 by Aurora-A may function as a bistable switch PMID: 24338364
    6. Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex. PMID: 23970419
    7. Following UV irradiation, ataxia telangiectasia-mutated- and Rad3-related protein phosphorylates Bora at Thr-501. The phosphorylated Thr-501 is subsequently recognized by the E3 ubiquitin ligase SCF-beta-TRCP, which targets Bora for degradation. PMID: 23592782
    8. Study concludes that tight regulation of the Bora protein by its synthesis and degradation is critical for cell cycle progression. PMID: 18378770
    9. study reports that the synergistic action of Bora & the kinase Aurora A controls G2-M transition; Bora accumulates in G2 phase & promotes Aur-A-mediated activation of Polo-like kinase 1, leading to activation of cyclin-dependent kinase 1 & mitotic entry PMID: 18566290
    10. Recent advances in the understanding of the functional crosstalk between Plk1 and Aurora-A before and during mitosis. PMID: 19487276

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  • 蛋白家族：
    BORA family
  • 数据库链接：

    HGNC: 24724

    OMIM: 610510

    KEGG: hsa:79866

    STRING: 9606.ENSP00000375082

    UniGene: Hs.643464