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  4. Recombinant Human Protein aurora borealis (BORA)

Recombinant Human Protein aurora borealis (BORA)

  • 货号：
    CSB-YP750873HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP750873HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP750873HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP750873HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP750873HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BORA
  • Uniprot No.：
  • 别名：
    Aurora borealis; bora; bora; aurora kinase A activator; BORA_HUMAN; C13orf34; Chromosome 13 open reading frame 34 ; FLJ22624; HsBora; Protein aurora borealis; RP11-342J4.2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-559
  • 氨基酸序列
    MGDVKESKMQ ITPETPGRIP VLNPFESPSD YSNLHEQTLA SPSVFKSTKL PTPGKFRWSI DQLAVINPVE IDPEDIHRQA LYLSHSRIDK DVEDKRQKAI EEFFTKDVIV PSPWTDHEGK QLSQCHSSKC TNINSDSPVG KKLTIHSEKS DAACQTLLSL PVDFNLENIL GDYFRADEFA DQSPGNLSSS SLRRKLFLDG NGSISDSLPS ASPGSPHSGV QTSLEMFYSI DLSPVKCRSP LQTPSSGQFS SSPIQASAKK YSLGSITSPS PISSPTFSPI EFQIGETPLS EQRKFTVHSP DASSGTNSNG ITNPCIRSPY IDGCSPIKNW SPMRLQMYSG GTQYRTSVIQ IPFTLETQGE DEEDKENIPS TDVSSPAMDA AGIHLRQFSN EASTHGTHLV VTAMSVTQNQ SSASEKELAL LQDVEREKDN NTVDMVDPIE IADETTWIKE PVDNGSLPMT DFVSGIAFSI ENSHMCMSPL AESSVIPCES SNIQMDSGYN TQNCGSNIMD TVGAESYCKE SDAQTCEVES KSQAFNMKQD HTTQRCWMKT ASPFQCSSP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the activation of AURKA at the onset of mitosis.
  • 基因功能参考文献：
    1. our findings demonstrated that Bora was overexpressed and served as an independent biomarker for poor prognosis in multiple adenocarcinomas. PMID: 28402276
    2. the mechanism of Plk1 activation and the potential role of Bora phosphorylation by Cdk1, is reported. PMID: 27831827
    3. These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry. PMID: 27068477
    4. Bora was found to play a significant role in radiosensitivity through the regulation of MDC1 and DNA repair. PMID: 25742493
    5. Activation of Plk1 by Aurora-A may function as a bistable switch PMID: 24338364
    6. Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex. PMID: 23970419
    7. Following UV irradiation, ataxia telangiectasia-mutated- and Rad3-related protein phosphorylates Bora at Thr-501. The phosphorylated Thr-501 is subsequently recognized by the E3 ubiquitin ligase SCF-beta-TRCP, which targets Bora for degradation. PMID: 23592782
    8. Study concludes that tight regulation of the Bora protein by its synthesis and degradation is critical for cell cycle progression. PMID: 18378770
    9. study reports that the synergistic action of Bora & the kinase Aurora A controls G2-M transition; Bora accumulates in G2 phase & promotes Aur-A-mediated activation of Polo-like kinase 1, leading to activation of cyclin-dependent kinase 1 & mitotic entry PMID: 18566290
    10. Recent advances in the understanding of the functional crosstalk between Plk1 and Aurora-A before and during mitosis. PMID: 19487276

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  • 蛋白家族：
    BORA family
  • 数据库链接：

    HGNC: 24724

    OMIM: 610510

    KEGG: hsa:79866

    STRING: 9606.ENSP00000375082

    UniGene: Hs.643464