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BRWD3 Antibody

  • 中文名称：
    BRWD3兔多克隆抗体
  • 货号：
    CSB-PA008526
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q6RI45
  • 基因名：
    BRWD3
  • 别名：
    BRWD3Bromodomain and WD repeat-containing protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human BRWD3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
  • 基因功能参考文献：
    1. BCL7A, BRWD3, and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations. PMID: 29166413
    2. A nonsense mutation in BRWD3 in a family with X-linked intellectual disability associated with macrocephaly. PMID: 24462886
    3. potential serological biomarker of breast cancer PMID: 22024541
    4. Includes the identification of truncating mutations in this gene that segregated with mental retardation in the families tested. PMID: 19377476
    5. BRWD3 is therefore a new gene implicated in the etiology of XLMR associated with macrocephaly and may cause disease by altering intracellular signaling pathways affecting cellular proliferation. PMID: 17668385

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  • 相关疾病：
    Mental retardation, X-linked 93 (MRX93)
  • 组织特异性：
    Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined.
  • 数据库链接：

    HGNC: 17342

    OMIM: 300553

    KEGG: hsa:254065

    STRING: 9606.ENSP00000362372

    UniGene: Hs.147027