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CADM2 Antibody

  • 货号：
    CSB-PA003005
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using IGSF4D Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8N3J6
  • 基因名：
    CADM2
  • 别名：
    CADM2 antibody; CADM2_HUMAN antibody; Cell adhesion molecule 2 antibody; IgSF4D antibody; Immunoglobulin superfamily member 4D antibody; NECL 2 antibody; Necl 3 antibody; NECL-3 antibody; NECL2 antibody; Necl3 antibody; Nectin like protein 3 antibody; Nectin-like protein 3 antibody; synCAM 2 antibody; synCAM2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human IGSF4D.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.
  • 基因功能参考文献：
    1. Ectopic expression of CADM2 counteracted the promoting effect of miR-146a on cell proliferation, migration, invasion, and the epithelial-mesenchymal transition process. PMID: 30184528
    2. CADM2 SNPs were associated with lifetime cannabis use, but the association did not reach genome-wide significance. [Meta-Analysis] PMID: 27023175
    3. A significant association was observed for the single-nucleotide polymorphism (SNP) rs17518584 and in the joint discovery and replication meta-analysis in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. PMID: 25869804
    4. In the absence of SynCAMs, selective axon-axon interactions are perturbed resulting in aberrant pathfinding of sensory axons. PMID: 25335893
    5. Cox regression analysis indicated that CADM2 expression level, tumor size, tumor number, vascular invasion, HBsAg were independent risk factors for HCC recurrence PMID: 24240726
    6. Thus, we conclude that CADM2 functions as a novel tumor suppressor and may serve as a potential therapeutic target for human renal cell carcinoma. PMID: 23643812
    7. The results indicated that CADM2 is one of the pathogenic factors for psoriasis. PMID: 21864505
    8. Its expression is regulated in part by promoter methylation and implicates CADM-2 as a previously unrecognized tumor suppressor gene in a proportion of human prostate cancers. PMID: 21062931
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19861958

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons.
  • 蛋白家族：
    Nectin family
  • 数据库链接：

    HGNC: 29849

    OMIM: 609938

    KEGG: hsa:253559

    STRING: 9606.ENSP00000384193

    UniGene: Hs.164578