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  4. Recombinant Human Cell adhesion molecule 2 (CADM2), partial

Recombinant Human Cell adhesion molecule 2 (CADM2), partial

  • 货号：
    CSB-YP004426HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004426HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004426HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004426HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004426HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CADM2
  • Uniprot No.：
  • 别名：
    CADM2; CADM2_HUMAN; Cell adhesion molecule 2; IgSF4D; Immunoglobulin superfamily member 4D; NECL 2; Necl 3; NECL-3; NECL2; Necl3; Nectin like protein 3; Nectin-like protein 3; synCAM 2; synCAM2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.
  • 基因功能参考文献：
    1. Ectopic expression of CADM2 counteracted the promoting effect of miR-146a on cell proliferation, migration, invasion, and the epithelial-mesenchymal transition process. PMID: 30184528
    2. CADM2 SNPs were associated with lifetime cannabis use, but the association did not reach genome-wide significance. [Meta-Analysis] PMID: 27023175
    3. A significant association was observed for the single-nucleotide polymorphism (SNP) rs17518584 and in the joint discovery and replication meta-analysis in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. PMID: 25869804
    4. In the absence of SynCAMs, selective axon-axon interactions are perturbed resulting in aberrant pathfinding of sensory axons. PMID: 25335893
    5. Cox regression analysis indicated that CADM2 expression level, tumor size, tumor number, vascular invasion, HBsAg were independent risk factors for HCC recurrence PMID: 24240726
    6. Thus, we conclude that CADM2 functions as a novel tumor suppressor and may serve as a potential therapeutic target for human renal cell carcinoma. PMID: 23643812
    7. The results indicated that CADM2 is one of the pathogenic factors for psoriasis. PMID: 21864505
    8. Its expression is regulated in part by promoter methylation and implicates CADM-2 as a previously unrecognized tumor suppressor gene in a proportion of human prostate cancers. PMID: 21062931
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19861958

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons.
  • 蛋白家族：
    Nectin family
  • 数据库链接：

    HGNC: 29849

    OMIM: 609938

    KEGG: hsa:253559

    STRING: 9606.ENSP00000384193

    UniGene: Hs.164578