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CAPRIN2 Antibody

  • 中文名称：
    CAPRIN2兔多克隆抗体
  • 货号：
    CSB-PA004506GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6IMN6
  • 基因名：
    CAPRIN2
  • 别名：
    C1q domain-containing protein 1 antibody; C1QDC1 antibody; CAPR2_HUMAN antibody; Caprin family member 2 antibody; Caprin-2 antibody; caprin2 antibody; Cytoplasmic activation/proliferation-associated protein 2 antibody; EEG 1 antibody; EEG1 antibody; Gastric cancer multidrug resistance-associated protein antibody; KIAA1873 antibody; Protein EEG-1 antibody; RNA granule protein 140 antibody; RNG140 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CAPRIN2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.
  • 基因功能参考文献：
    1. findings revealed an unrecognized role of Caprin-2 in facilitating LRP5/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14, Cyclin Y, and LRP5/6. PMID: 27821587
    2. Caprin-2 C1q-related domain forms a flexible homotrimer mediated by calcium, and this trimeric assembly is required for the functioning of caprin-2. PMID: 25331957
    3. regulated expression of EEG-1 is involved in the orchestrated regulation of growth that occurs as erythroblasts shift from a highly proliferative state toward their terminal phase of differentiation. PMID: 14593112
    4. Caprin-2 promotes activation of the canonical Wnt signaling pathway by regulating LRP5/6 phosphorylation. PMID: 18762581
  • 亚细胞定位：
    [Isoform 1]: Cytoplasm.; [Isoform 2]: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm.; [Isoform 5]: Mitochondrion. Note=Colocalizes with aggregated mitochondria.; Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Caprin family
  • 组织特异性：
    Detected in all tissues tested with highest levels of expression in brain and spleen.
  • 数据库链接：

    HGNC: 21259

    OMIM: 610375

    KEGG: hsa:65981

    UniGene: Hs.234355