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CGNL1 Antibody

  • 中文名称：
    CGNL1兔多克隆抗体
  • 货号：
    CSB-PA005304GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q0VF96
  • 基因名：
    CGNL1
  • 别名：
    Cgnl1 antibody; CGNL1_HUMAN antibody; Cingulin like 1 antibody; Cingulin-like protein 1 antibody; FLJ14957 antibody; JACOP antibody; Junction-associated coiled-coil protein antibody; KIAA1749 antibody; MGC138254 antibody; Paracingulin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CGNL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons.
  • 基因功能参考文献：
    1. demonstrate in a postnatal retinal vascular development model in mice that Cgnl1 function is crucial for sustaining neovascular growth and stability PMID: 29016873
    2. Results indentify plausible candidates include non-recurrent deletions at the glutamate transporter gene SLC1A1, a CNV locus recently suggested to be involved in schizophrenia through linkage analysis, and duplications at 1p36.33 and CGNL1. PMID: 24163246
    3. ZO-1 and PLEKHA7 are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively PMID: 21454477
    4. Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions PMID: 18653465
    5. This paper studied the mouse JACOP protein and found that the JACOP protein has structural and functional similarities to cingulin. PMID: 15292197

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  • 相关疾病：
    Aromatase excess syndrome (AEXS)
  • 亚细胞定位：
    Cell junction, tight junction.
  • 蛋白家族：
    Cingulin family
  • 组织特异性：
    Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus and subthalamic nucleus of adult brain.
  • 数据库链接：

    HGNC: 25931

    OMIM: 139300

    KEGG: hsa:84952

    STRING: 9606.ENSP00000281282

    UniGene: Hs.148989