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CHMP4C Antibody

  • 货号：
    CSB-PA853396LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA853396LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CHMP4C Polyclonal antibody
  • Uniprot No.：
    Q96CF2
  • 基因名：
  • 别名：
    Charged multivesicular body protein 4c antibody; CHM4C_HUMAN antibody; CHMP4c antibody; Chromatin-modifying protein 4c antibody; hSnf7-3 antibody; hVps32-3 antibody; SHAX3 antibody; SNF7 homolog associated with Alix 3 antibody; SNF7-3 antibody; Vacuolar protein sorting-associated protein 32-3 antibody; Vps32-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Charged multivesicular body protein 4c protein (1-233AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CHMP4C Antibody (CSB-PA853396LA01HU)，的标记方式是Non-conjugated。对于CHMP4C Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA853396LB01HU CHMP4C Antibody, HRP conjugated ELISA
    FITC CSB-PA853396LC01HU CHMP4C Antibody, FITC conjugated
    Biotin CSB-PA853396LD01HU CHMP4C Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan.
  • 基因功能参考文献：
    1. Data demonstrate the biological importance of the abscission checkpoint and suggest that dysregulation of abscission by CHMP4CT232 may synergize with oncogene-induced mitotic stress to promote genomic instability and tumorigenesis. PMID: 30181294
    2. Results show that CHMP4C, under the regulation of the chromosomal passenger complex, binds to highly curved membranes and promotes the closure of membrane gaps. Two distinctly localized pools of phosphorylated CHMP4C exist during cytokinesisI but the phosphorylation is not required for its assembly into spiral filaments. Also, the centralspindlin complex associates preferentially with the with unphosphorylated form. PMID: 27784789
    3. CHMP4C mediates radiation resistance in lung cancer cells. PMID: 26712741
    4. The ESCRT-III subunit CHMP4B is a key effector in abscission, whereas its paralogue, CHMP4C, is a component in the abscission checkpoint that delays abscission until chromatin is cleared from the intercellular bridge. PMID: 26929449
    5. AURKB phosphorylates CHMP4C at 3 serines its C-terminal tail.Phosphorylation at these sites appears essential for CHMP4C function because their mutation leads to cytokinesis defects. PMID: 22724069
    6. Single nucleotide polymorphisms in CHMP4C gene is associated with ovarian cancer. PMID: 23535730
    7. findings show CHMP4C is involved in abscission timing; this function correlated with its differential spatiotemporal distribution during late stages of cytokinesis; CHMP4C functioned in the Aurora B-dependent abscission checkpoint PMID: 22422861
    8. The Bro1 domain of ALIX binds specifically to C-terminal residues of the human CHMP4C. PMID: 18511562

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  • 亚细胞定位：
    Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein. Midbody, Midbody ring.
  • 蛋白家族：
    SNF7 family
  • 组织特异性：
    Expressed in heart, spleen and kidney.
  • 数据库链接：

    HGNC: 30599

    OMIM: 610899

    KEGG: hsa:92421

    STRING: 9606.ENSP00000297265

    UniGene: Hs.183861