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CHRD Antibody

  • 中文名称：
    CHRD兔多克隆抗体
  • 货号：
    CSB-PA875601
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human-liver-cancer, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-liver-cancer, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q9H2X0
  • 基因名：
  • 别名：
    CHRD antibody; UNQ217/PRO243Chordin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 905-954
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
  • 基因功能参考文献：
    1. Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling. PMID: 26517884
    2. C-terminal chordin domains play an important role in Bone morphogenetic protein regulation. PMID: 25157165
    3. chordin silencing increased osteogenic differentiation without supplemented BMP-2. PMID: 23931154
    4. results suggest that CHRD could participate in regulating BMP activity in normal ovarian surface epithelium physiology, and that its mis-expression in ovarian surface epithelium may facilitate cancer incidence and/or progression PMID: 16449796
    5. Bone morphogenetic protein (BMP) chordin is produced endogenously during osteogenic differentiation of human mesenchymal stem cells (MSCs); blockade of bone morphogenetic inhibitor chordin increases the rate of osteogenic differentiation of MSCs in vitro. PMID: 18533030
    6. Noggin and chordin were also expressed most intensely in areas of cartilage formation and there was no difference in their expression between the non-hypertrophic and hypertrophic chondrocytes. PMID: 19023570
    7. there was no difference in the expression of the noggin and chordin between healing and nonhealing fractures PMID: 19058174
    8. Alternatively spliced variants have different patterns of expression to influence BMP activity in varying physiolgical situations. PMID: 11472837

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Chordin family
  • 组织特异性：
    Expressed at the highest level in liver.
  • 数据库链接：

    HGNC: 1949

    OMIM: 603475

    KEGG: hsa:8646

    STRING: 9606.ENSP00000204604

    UniGene: Hs.166186