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CHTF18 Antibody

  • 中文名称：
    CHTF18兔多克隆抗体
  • 货号：
    CSB-PA005418GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8WVB6
  • 基因名：
    CHTF18
  • 别名：
    6030457M03Rik antibody; C16orf41 antibody; C321D2.2 antibody; C321D2.3 antibody; C321D2.4 antibody; CHL12 antibody; chromosome transmission fidelity factor 18 homolog (S. cerevisiae) antibody; Chromosome transmission fidelity protein 18 homolog antibody; chtf18 antibody; Ctf18 antibody; CTF18_HUMAN antibody; hCTF18 antibody; MGC38008 antibody; RUVBL antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CHTF18
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage.
  • 基因功能参考文献：
    1. Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp. PMID: 28199690
    2. CTF18 forms a complex with RPA when replication stress is elicited by hydroxyurea treatment or UV exposure during S phase. The interaction kinetics between CTF18 and RPA is positively associated with the phosphorylation status of Chk1. PMID: 27175616
    3. This is the first report of somatic mutations within ESCO1 and CHTF18 in endometrial tumors and of MRE11A mutations in microsatellite-stable endometrial tumors. PMID: 23755103
    4. identification as proliferating cell nuclear antigen-binding protein PMID: 12171929
    5. Ctf18-RFC interacts physically with pol eta, which allows DNA replication forks to overcome interference by various template structures, including damaged DNA and DNA-protein complexes that maintain chromosome cohesion PMID: 17545166
    6. hChlR1 has a role in the establishment of sister chromatid cohesion, with Ctf18-RFC and Fen1 PMID: 18499658

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  • 亚细胞定位：
    Nucleus. Note=Associates with chromatin during S phase.
  • 蛋白家族：
    Activator 1 small subunits family, CTF18 subfamily
  • 数据库链接：

    HGNC: 18435

    OMIM: 613201

    KEGG: hsa:63922

    STRING: 9606.ENSP00000262315

    UniGene: Hs.153850