Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. CHTF18 Antibody

CHTF18 Antibody

  • 中文名称：
    CHTF18兔多克隆抗体
  • 货号：
    CSB-PA005418GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8WVB6
  • 基因名：
    CHTF18
  • 别名：
    6030457M03Rik antibody; C16orf41 antibody; C321D2.2 antibody; C321D2.3 antibody; C321D2.4 antibody; CHL12 antibody; chromosome transmission fidelity factor 18 homolog (S. cerevisiae) antibody; Chromosome transmission fidelity protein 18 homolog antibody; chtf18 antibody; Ctf18 antibody; CTF18_HUMAN antibody; hCTF18 antibody; MGC38008 antibody; RUVBL antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CHTF18
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. ...显示更多
  • 基因功能参考文献：
    1. Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp. PMID: 28199690
    2. CTF18 forms a complex with RPA when replication stress is elicited by hydroxyurea treatment or UV exposure during S phase. The interaction kinetics between CTF18 and RPA is positively associated with the phosphorylation status of Chk1. PMID: 27175616
    3. This is the first report of somatic mutations within ESCO1 and CHTF18 in endometrial tumors and of MRE11A mutations in microsatellite-stable endometrial tumors. PMID: 23755103
    4. identification as proliferating cell nuclear antigen-binding protein PMID: 12171929
    5. Ctf18-RFC interacts physically with pol eta, which allows DNA replication forks to overcome interference by various template structures, including damaged DNA and DNA-protein complexes that maintain chromosome cohesion PMID: 17545166
    6. hChlR1 has a role in the establishment of sister chromatid cohesion, with Ctf18-RFC and Fen1 PMID: 18499658

    收起更多

  • 亚细胞定位：
    Nucleus. Note=Associates with chromatin during S phase.
  • 蛋白家族：
    Activator 1 small subunits family, CTF18 subfamily
  • 数据库链接：

    HGNC: 18435

    OMIM: 613201

    KEGG: hsa:63922

    STRING: 9606.ENSP00000262315

    UniGene: Hs.153850