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CLEC4G Antibody

  • 中文名称：
    CLEC4G兔多克隆抗体
  • 货号：
    CSB-PA744269LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA744269LA01HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CLEC4G Polyclonal antibody
  • Uniprot No.：
    Q6UXB4
  • 基因名：
    CLEC4G
  • 别名：
    C type lectin domain family 4; member G antibody; C type lectin superfamily 4; member G antibody; C-type lectin domain family 4 member G antibody; CLC4G_HUMAN antibody; Clec4g antibody; DTTR431 antibody; Liver and lymph node sinusoidal endothelial cell C type lectin antibody; LP2698 antibody; LSECtin antibody; UNQ431 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human C-type lectin domain family 4 member G protein (66-293AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CLEC4G Antibody (CSB-PA744269LA01HU)，的标记方式是Non-conjugated。对于CLEC4G Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA744269LB01HU CLEC4G Antibody, HRP conjugated ELISA
    FITC CSB-PA744269LC01HU CLEC4G Antibody, FITC conjugated
    Biotin CSB-PA744269LD01HU CLEC4G Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.; (Microbial infection) Acts as a receptor for Japanese encephalitis virus.; (Microbial infection) Acts as a receptor for Ebolavirus.; (Microbial infection) Acts as a receptor for SARS-CoV.; (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein.
  • 基因功能参考文献：
    1. Japanese encephalitis virus infected cells through three virus receptors: DC-SIGN, DC-SIGNR and LSECtin. PMID: 24623090
    2. The results indicate that LSECtin plays an important role in colorectal carcinoma liver metastasis and may be a promising new target for intervention in metastasis formation. PMID: 22637699
    3. The mobility of LSECtin-carbohydrate recognition domain increased after addition of Ca(2+) and N-acetylglucosamine. PMID: 22711492
    4. Axl,Tyro3,DC-SIGN and LSECtin are identified as new virus receptors for Lassa virus cell entry. PMID: 22156524
    5. The human LSECtin have been shown to bind Ebola virus glycoprotein with equivalent affinities, and the GlcNAcbeta1-2Man disaccharide has been demonstrated to be an effective inhibitor of this interaction. PMID: 21257728
    6. The interaction between CD44 & LSECtin is dependent on protein-glycan recognition. CD44 is the 1st identified endogenous ligand of LSECtin, & similarly, LSECtin is a novel ligand of CD44. PMID: 20127679
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20237496
    8. results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor PMID: 14711836
    9. LSECtin is a pathogen-associated molecular pattern receptor in human myeloid cells; results suggest that LSECtin participates in antigen uptake and internalization PMID: 17339424
    10. Our results reveal important differences between Ebola virus and HIV-1 capture by DC-SIGN/R and LSECtin and hint towards different biological functions of these lectins. PMID: 18083206
    11. LSECtin is expressed by liver myeloid cells, and its expression is dependent on the PU.1 transcription factor. PMID: 19111020
    12. Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response. PMID: 19632227
    13. Observational study of gene-disease association. (HuGE Navigator) PMID: 18697825

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Expressed exclusively in fetal and adult liver and in lymph nodes. Specifically expressed by endothelial cells lining lymph node and liver sinuses (at protein level).
  • 数据库链接：

    HGNC: 24591

    OMIM: 616256

    KEGG: hsa:339390

    STRING: 9606.ENSP00000327599

    UniGene: Hs.220649