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CNKSR3 Antibody

  • 中文名称：
    CNKSR3兔多克隆抗体
  • 货号：
    CSB-PA005654GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6P9H4
  • 基因名：
    CNKSR3
  • 别名：
    CNKSR3 antibody; MAGI1Connector enhancer of kinase suppressor of ras 3 antibody; Connector enhancer of KSR 3 antibody; CNK homolog protein 3 antibody; CNK3 antibody; CNKSR family member 3 antibody; Maguin-like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CNKSR3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).
  • 基因功能参考文献：
    1. SCAF8-CNKSR3 variant rs955333 was not associated with diabetic kidney disease but showed association with diabetic retinopathy in Chinese type 2 diabetes patients PMID: 28401168
    2. Cox regression and Kaplan-Meier survival analysis identified that amplification of the CNKSR3 gene (log-rank, P = 0.022) with an associated increase in its protein expression (log-rank, P = 0.011) correlated with longer patient survival. PMID: 23357503
    3. CNK3 is a molecular scaffold, which coordinates the assembly of a multiprotein ENaC-regulatory complex and hence plays a central role in Na(+) homeostasis. PMID: 22851176
    4. two gene markers (CNKSR3 and SPTBN2) differentiate between aspirin-exacerbated respiratory disease and aspirin-tolerant asthma with a perfect discriminative power PMID: 22457146
    5. CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration. PMID: 22085542
    6. CNKSR3, a homologue of scaffold proteins involved in MAPK pathway regulation, is a direct target of MR and is required for the maintenance of transepithelial sodium transport in the kidney. PMID: 19567370

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  • 亚细胞定位：
    Cytoplasm. Apical cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    CNKSR family
  • 数据库链接：

    HGNC: 23034

    OMIM: 617476

    KEGG: hsa:154043

    STRING: 9606.ENSP00000356182

    UniGene: Hs.16064