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CNTN6 Antibody

  • 货号：
    CSB-PA008872
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UQ52
  • 基因名：
    CNTN6
  • 别名：
    CNTN 6 antibody; CNTN6 antibody; CNTN6_HUMAN antibody; Contactin 6 precursor antibody; Contactin-6 antibody; Contactin6 antibody; hNB 3 antibody; hNB-3 antibody; hNB3 antibody; MGC133256 antibody; NB 3 antibody; NB3 antibody; Neural adhesion molecule antibody; Neural recognition molecule NB 3 antibody; Neural recognition molecule NB-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Contactin 6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.
  • 基因功能参考文献：
    1. Clinical investigations of the patients carrying CNTN5 or CNTN6 variants showed that they were hypersensitive to sounds (a condition called hyperacusis) and displayed changes in wave latency within the auditory pathway. PMID: 27166760
    2. CNTN6 copy number variants (duplications) were associated with increased risk of Tourette syndrome. PMID: 28641109
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Immunoglobulin superfamily, Contactin family
  • 组织特异性：
    Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.
  • 数据库链接：

    HGNC: 2176

    OMIM: 607220

    KEGG: hsa:27255

    STRING: 9606.ENSP00000341882

    UniGene: Hs.387300