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COX6A1 Antibody

  • 货号：
    CSB-PA005847GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P12074
  • 基因名：
  • 别名：
    COX VIa L antibody; COX VIa-L antibody; COX6A antibody; COX6A1 antibody; COX6AL antibody; CX6A1_HUMAN antibody; Cytochrome c oxidase polypeptide VIa liver antibody; Cytochrome c oxidase polypeptide VIa-liver antibody; Cytochrome c oxidase subunit 6A1 antibody; Cytochrome c oxidase subunit 6A1 mitochondrial antibody; Cytochrome C oxidase subunit VIa homolog antibody; Cytochrome c oxidase subunit VIA liver antibody; Cytochrome c oxidase subunit VIa polypeptide 1 antibody; Cytochrome c oxidase subunit VIA-liver antibody; MGC104500 antibody; mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human COX6A1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能参考文献：
    1. We demonstrate a developmental isoform switch of COX6A and COX7A subunits in human and mouse skeletal muscle PMID: 25666558
    2. Mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease. PMID: 25152455
    3. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 6a PMID: 20307258
    4. COX6A1 was identified as the protein that inhibits yeast cells Bax-sensitivity and protects mammalian cells from 4-HPR-induced apoptosis. PMID: 18549809
  • 相关疾病：
    Charcot-Marie-Tooth disease, recessive, intermediate type, D (CMTRID)
  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    Cytochrome c oxidase subunit 6A family
  • 数据库链接：

    HGNC: 2277

    OMIM: 602072

    KEGG: hsa:1337

    STRING: 9606.ENSP00000229379

    UniGene: Hs.369624