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COX6A1 Antibody

  • 货号：
    CSB-PA02315A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: COX6A1 antibody at 2µg/ml + EC109 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 13 kDa
      Observed band size: 13 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA02315A0Rb at dilution of 1:100
    • Immunofluorescent analysis of NIH/3T3 cells using CSB-PA02315A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) COX6A1 Polyclonal antibody
  • Uniprot No.：
    P12074
  • 基因名：
  • 别名：
    COX VIa L antibody; COX VIa-L antibody; COX6A antibody; COX6A1 antibody; COX6AL antibody; CX6A1_HUMAN antibody; Cytochrome c oxidase polypeptide VIa liver antibody; Cytochrome c oxidase polypeptide VIa-liver antibody; Cytochrome c oxidase subunit 6A1 antibody; Cytochrome c oxidase subunit 6A1 mitochondrial antibody; Cytochrome C oxidase subunit VIa homolog antibody; Cytochrome c oxidase subunit VIA liver antibody; Cytochrome c oxidase subunit VIa polypeptide 1 antibody; Cytochrome c oxidase subunit VIA-liver antibody; MGC104500 antibody; mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cytochrome c oxidase subunit 6A1, mitochondrial protein (25-109AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，COX6A1 Antibody (CSB-PA02315A0Rb)，的标记方式是Non-conjugated。对于COX6A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA02315B0Rb COX6A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA02315C0Rb COX6A1 Antibody, FITC conjugated
    Biotin CSB-PA02315D0Rb COX6A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能参考文献：
    1. We demonstrate a developmental isoform switch of COX6A and COX7A subunits in human and mouse skeletal muscle PMID: 25666558
    2. Mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease. PMID: 25152455
    3. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 6a PMID: 20307258
    4. COX6A1 was identified as the protein that inhibits yeast cells Bax-sensitivity and protects mammalian cells from 4-HPR-induced apoptosis. PMID: 18549809
  • 相关疾病：
    Charcot-Marie-Tooth disease, recessive, intermediate type, D (CMTRID)
  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    Cytochrome c oxidase subunit 6A family
  • 数据库链接：

    HGNC: 2277

    OMIM: 602072

    KEGG: hsa:1337

    STRING: 9606.ENSP00000229379

    UniGene: Hs.369624