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CPSF1 Antibody

  • 中文名称：
    CPSF1兔多克隆抗体
  • 货号：
    CSB-PA005914GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q10570
  • 基因名：
    CPSF1
  • 别名：
    CPSF1 antibody; CPSF160Cleavage and polyadenylation specificity factor subunit 1 antibody; Cleavage and polyadenylation specificity factor 160 kDa subunit antibody; CPSF 160 kDa subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CPSF1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain.
  • 基因功能参考文献：
    1. Knockdown of CPSF inhibits the proliferation, migration and invasion of ovarian carcinoma cells. PMID: 29358555
    2. CPSF1 was identified among protein-binding candidates. A consensus polyadenylation signal AAUAAA is present in intron 6 of IL7 receptor directly downstream from the 5' splice site. Mutations to this site and CPSF1 knockdown increased exon 6 inclusion. PMID: 23151878
  • 亚细胞定位：
    Nucleus, nucleoplasm.
  • 蛋白家族：
    CPSF1 family
  • 组织特异性：
    Widely expressed, with high expression in the retina.
  • 数据库链接：

    HGNC: 2324

    OMIM: 606027

    KEGG: hsa:29894

    STRING: 9606.ENSP00000339353

    UniGene: Hs.493202