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CRLS1 Antibody

  • 中文名称：
    CRLS1兔多克隆抗体
  • 货号：
    CSB-PA005985GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UJA2
  • 基因名：
    CRLS1
  • 别名：
    CRLS1; C20orf155; CLS1; Cardiolipin synthase; CMP-forming; CLS; Protein GCD10 homolog
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human CRLS1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.
  • 基因功能参考文献：
    1. Knockdown of human CRLS1 leads to a cardiolipin decrease, phosphatidylglycerol accumulation and mitochondrial elongation. PMID: 29251771
    2. transgenic expression of cardiolipin synthase attenuated maladaptive cardiolipin remodeling and bioenergetic inefficiency in myocardium rendered diabetic by streptozotocin treatment. PMID: 22584571
    3. CLS mRNA levels cannot be correlated with CLS enzyme activity nor CL content in the LPS model of inflammation. PMID: 20652826
    4. A human candidate gene/cDNA for cardiolipin synthase, C20orf155, was identified. PMID: 16678169
    5. hCLS1 protein was localized to the mitochondria when transiently expressed in COS-7 cells PMID: 16716149
    6. We describe here a human gene for CLS and its analysis via RNAi knockdown on apoptotic progression. PMID: 16888643
    7. anti-cardiolipin antibody positivity is an independent predictor of chronic renal failure PMID: 19048414
    8. Patients with solid and non-solid malignancies display anticardiolipin antibodies associated with increased rate of thrombosis PMID: 19048416
    9. presence of cardiolipin autoantibodies is criteria for diagnostics of antiphospholipid syndrome PMID: 19052923
    10. associated with Libman-Sacks endocarditis, cardiac manifestation of SLE PMID: 19089657
    11. antibodies occur frequently in viral infections, particularly, in HIV but not in bacterial infections PMID: 19089659

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  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    CDP-alcohol phosphatidyltransferase class-I family
  • 组织特异性：
    Highly expressed in tissues such as heart, skeletal muscle and liver.
  • 数据库链接：

    HGNC: 16148

    OMIM: 608188

    KEGG: hsa:54675

    STRING: 9606.ENSP00000368140

    UniGene: Hs.743956