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  4. DHRS11 Antibody

DHRS11 Antibody

  • 中文名称：
    DHRS11兔多克隆抗体
  • 货号：
    CSB-PA060136
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q6UWP2
  • 基因名：
    DHRS11
  • 别名：
    DHRS11 antibody; SDR24C1 antibody; UNQ836/PRO1774Dehydrogenase/reductase SDR family member 11 antibody; 17-beta-hydroxysteroid dehydrogenase antibody; 3-beta-hydroxysteroid 3-dehydrogenase antibody; EC 1.1.1.270 antibody; Estradiol 17-beta-dehydrogenase antibody; EC 1.1.1.62 antibody; Short-chain dehydrogenase/reductase family 24C member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human DHRS11.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.
  • 基因功能参考文献：
    1. The recombinant protein (DHRS11) efficiently catalyzed the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5alpha-androstanes into their 17beta-hydroxyl metabolites with NADPH as a coenzyme. PMID: 26920053
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 组织特异性：
    Isoform 1: Ubiquitously expressed, with highest levels in testis, small intestine, colon, kidney, brain and heart. Isoform 3: Expressed in brain, heart and skeletal muscle.
  • 数据库链接：

    HGNC: 28639

    OMIM: 616159

    KEGG: hsa:79154

    STRING: 9606.ENSP00000251312

    UniGene: Hs.462859